Scutellarin Attenuates the IL-1 β-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression

Osteoarthritis (OA) is a chronic degenerative disease wherein the articular cartilage exhibits inflammation and degradation. Scutellarin (SCU) is a flavonoid glycoside with a range of pharmacological activities, as shown in previous studies demonstrating its anti-inflammatory activity. How SCU impacts the progression of OA, however, has not been explored to date. Herein, we assessed the impact of SCU on murine chondrocytes in an OA model system. In in vitro assays, we measured chondrocyte expression of key OA-associated factors such as matrix metalloproteinase 13 (MMP-13), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) via qRT-PCR and Western blotting, the expression of interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and prostaglandin E2 (PGE2) were detected by qRT-PCR. Our results showed that the downregulation of MMP-13, ADAMTS-5, COX-2, and iNOS expression by SCU and the overproduction of IL-6, TNF-α, and PGE2 induced by IL-1β were all inhibited by SCU in a concentration-dependent manner. Moreover, SCU was able to reverse aggrecan and collagen II degradation and nuclear factor-κB (NF-κB) and nuclear factor erythroid-derived 2-like 2 (Nrf2) signaling pathway activation both in vivo and in vitro. We further used a destabilization of the medial meniscus (DMM) murine model of OA to explore the therapeutic benefits of SCU in vivo. Together...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Authors: Kolz JM, Rainer WG, Wyles CC, Houdek MT, Perry KI, Lewallen DG Abstract BACKGROUND: Lymphedema is characterized by fluid buildup and swelling, leading to skin fibrosis and recurring soft-tissue infections. There is a paucity of data examining the impact of lymphedema in total knee arthroplasty (TKA). The purpose of this study was to review the outcomes of TKA in patients with lymphedema compared with a matched cohort with primary osteoarthritis. METHODS: One hundred forty-four knees underwent primary TKA with a preceding diagnosis of ipsilateral lymphedema. The mean follow-up was 7 years. A blinded 1:2...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Conditions:   Patient Satisfaction;   Hip Osteoarthritis Interventions:   Procedure: large head;   Procedure: dual mobility cup Sponsor:   Tanta University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Symptomatic Osteoarthritis of the Knee With Kellgren-Lawrence Grade II and III Interventions:   Drug: JTA-004;   Device: Hylan G-F 20;   Other: placebo Sponsors:   Bone Therapeutics S.A;   Nordic Bioscience A/S Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Patellofemoral Osteoarthritis Interventions:   Device: Elastic hip strap;   Device: Insole Sponsors:   Universidade Federal de Sao Carlos;   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionIn patients with symptomatic knee OA, the presence of knee CC did not affect the risk of arthroplasty or disease progression at 5 years.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Conditions:   Osteo Arthritis Knee;   Pain, Chronic;   Pain Intervention:   Other: Dry cupping therapy Sponsor:   Universidade Federal do Rio Grande do Norte Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Decision Making, Shared;   Arthroplasty, Replacement, Knee;   Arthroplasty, Replacement, Hip;   Osteoarthritis, Knee;   Osteoarthritis, Hip;   Artificial Intelligence Intervention:   Other: ERVIN Sponsors:   Northern Orthopaedic Division, Denmark;   Aalborg University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Knee Osteoarthritis Interventions:   Other: Standard Physcial Therapy;   Other: Intermittent Mechanical Traction;   Other: Continuous Mechanical Traction Sponsor:   Prince Sultan Military College of Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Osteo Arthritis Knee Intervention:   Drug: allogenic lyophilized growth factors Sponsor:   Rasmia Elgohary Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Osteo Arthritis Knee;   Pain, Chronic;   Pain Intervention:   Other: Dry cupping therapy Sponsor:   Universidade Federal do Rio Grande do Norte Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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