A Deterministic Model for Q Fever Transmission Dynamics within Dairy Cattle Herds: Using Sensitivity Analysis and Optimal Controls.

A Deterministic Model for Q Fever Transmission Dynamics within Dairy Cattle Herds: Using Sensitivity Analysis and Optimal Controls. Comput Math Methods Med. 2020;2020:6820608 Authors: Asamoah JKK, Jin Z, Sun GQ, Li MY Abstract This paper presents a differential equation model which describes a possible transmission route for Q fever dynamics in cattle herds. The model seeks to ascertain epidemiological and theoretical inferences in understanding how to avert an outbreak of Q fever in dairy cattle herds (livestock). To prove the stability of the model's equilibria, we use a matrix-theoretic method and a Lyapunov function which establishes the local and global asymptotic behaviour of the model. We introduce time-dependent vaccination, environmental hygiene, and culling and then solve for optimal strategies. The optimal control strategies are necessary management practices that may increase animal health in a Coxiella burnetii-induced environment and may also reduce the transmission of the disease from livestock into the human population. The sensitivity analysis presents the relative importance of the various generic parameters in the model. We hope that the description of the results and the optimality trajectories provides some guidelines for animal owners and veterinary officers on how to effectively minimize the bacteria and control cost before/during an outbreak. PMID: 32089730 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research