Inhibition of Glycine Transporter-I as a Novel Mechanism for the Treatment of Depression

Conclusions: Our preliminary findings suggest that enhancing NMDA function can improve depression-like behaviors in rodent models and in human depression. Establishment of glycine transporter-I inhibition as a novel treatment for depression waits for confirmation by further proof-of-principle studies.

Source: Biological Psychiatry - April 4, 2013 Category: Psychiatry Authors: Chih-Chia Huang, I-Hua Wei, Chieh-Liang Huang, Kuang-Ti Chen, Mang-Hung Tsai, Priscilla Tsai, Rene Tun, Kuo-Hao Huang, Yue-Cune Chang, Hsien-Yuan Lane, Guochuan Emil Tsai Tags: Archival Reports Source Type: research