Corticomuscular control of walking in older people and people with Parkinson's disease - Roeder L, Boonstra TW, Kerr GK.
Changes in human gait resulting from ageing or neurodegenerative diseases are multifactorial. Here we assess the effects of age and Parkinson's disease (PD) on corticospinal activity recorded during treadmill and overground walking. Electroencephalography ...
Publication date: 28 March 2020Source: New Scientist, Volume 245, Issue 3275Author(s): Clare Wilson
This study presents a new approach based on a recurrent neural network (RNN) and a single waist-worn triaxial accelerometer to enhance the FOG detection performance to be used in real home-environments. Also, several machine and deep learning approaches for FOG detection are evaluated using a leave-one-subject-out (LOSO) cross-validation. Results show that modeling spectral information of adjacent windows through an RNN can bring a significant improvement in the performance of FOG detection without increasing the length of the analysis window (required to using it as a cue-system).
CONCLUSIONS DEGs, including SORT1, CRYAB, PSMA1, and SDHA may have roles in the pathogenesis of PD through the MAPK, Wnt, and Notch signaling pathways. PMID: 32210219 [PubMed - in process]
Conclusion: In idiopathic PD with MCI, atomoxetine does not improve complex attention. Also, a deteriorative trend in the executive function was noted. PMID: 32211146 [PubMed]
Authors: Tatullo M, Marrelli B, Zullo MJ, Codispoti B, Paduano F, Benincasa C, Fortunato F, Scacco S, Zavan B, Cocco T Abstract The scientific community continuously strives to get new disease models, to discover early markers or novel therapeutic approaches, improving the diagnosis and prognosis of several human pathologies. Parkinson's Disease (PD) is characterized by a long asymptomatic phase, characterized by a selective loss of dopaminergic neurons. Recently, the human Periapical Cyst-Mesenchymal Stem Cells (hPCy-MSCs) have been differentiated in functional dopaminergic neurons: such oral-derived MSCs and the ...
To investigate the effect of task prioritization on dual-task control in Parkinson disease (PD) associated with different postural impairments.
Publication date: Available online 27 March 2020Source: NeuroImage: ClinicalAuthor(s): Stefan Lang, Eun Jin Yoon, Mekale Kibreab, Iris Kathol, Jenelle Cheetham, Tracy Hammer, Justyna Sarna, Zahinoor Ismail, Oury Monchi
Authors: Liu H, Liu M, Zhang S, Li W, Wang A, Yang F, Jiang H PMID: 32208409 [PubMed - as supplied by publisher]
(Hokkaido University) A new technique allows researchers to test how the deformation of tiny train track-like cell proteins affects their function. The findings could help clarify the roles of deformed 'microtubules' in traumatic brain injuries and in neurological diseases like Parkinson's.
l-dopa-carbidopa intestinal gel (LCIG) is a validated method of optimizing levodopa (LD) administration in advanced Parkinson's disease (PD).