Cross-sectional study identifies lower risk of Staphylococcus aureus nasal colonisation in Danish blood donors with Hidradenitis suppurativa symptoms.
Cross-sectional study identifies lower risk of Staphylococcus aureus nasal colonisation in Danish blood donors with Hidradenitis suppurativa symptoms. Br J Dermatol. 2020 Feb 20;: Authors: Dinh KM, Erikstrup LT, Andersen RK, Andersen PS, Mikkelsen S, Kjerulff BD, Burgdorf KS, Hansen TF, Nielsen KR, Hjalgrim H, Jemec GB, Ullum H, Erikstrup C, Pedersen OB Abstract Hidradenitis suppurativa (HS) is a chronic skin disease with point prevalence between 1% and 4%, characterized by recurrent inflammation and painful formation of nodules in the intertriginous areas of the skin. In some patients, these lesions progress into the formation of abscesses and/or tunnels, ultimately causing restrictive scaring, and health-related quality of life impairment. Growing evidence suggests that the primary event is infundibular hyperkeratosis at the terminal follicles causing follicle dilatation and perifollicular inflammation followed by cyst formation.1 However, the exact aetiology of HS is still unknown, but likely multifactorial with involvement of genetic and immunological factors. PMID: 32078163 [PubMed - as supplied by publisher]
PMID: 31403170 [PubMed - as supplied by publisher]
CONCLUSION: Adults and children with HS had increased acute and chronic, cutaneous, extra-cutaneous, and systemic infections, which were associated with increased mortality and cost. This article is protected by copyright. All rights reserved. PMID: 31049925 [PubMed - as supplied by publisher]
Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The most frequentS. aureus infections include impetigo, folliculitis, furuncles, furunculosis, abscesses, hidradenitis suppurativa, and mastitis.S. aureus produces a great variety of cellular and extracellular factors responsible for its invasiveness and ability to cause pathological lesions. Their expression depends on the growth phase, environmental factors, and location of the infection. Susceptibility to staphylococcal infections is rooted in multiple mechanisms of host immune responses and reactions to bacterial colonization. Immunol...
This article is protected by copyright. All rights reserved. PMID: 30430552 [PubMed - as supplied by publisher]
CONCLUSIONS: In our study the rate of positive cultures increased in more severe stages of the disease, thus bacterial superinfection of established lesions may contribute to maintain chronic inflammation. We could not find statistically significant correlation with the sampled anatomic area or specific group of bacteria. Larger prospective studies should be performed. PMID: 29683279 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved. PMID: 28626900 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved.
Conclusions: Our findings on bacterial species and their topographical distribution revealed that the microbial flora in HS lesions reflects commensal flora of the skin. Due to the susceptibility rate and immunomodulatory and anti-inflammatory properties, cotrimoxazole may represent an alternative antibiotic agent and should be considered for therapy in HS patients.Skin Pharmacol Physiol 2016;29:161-167
In conclusion, an unregulated inflammation may cause the lesions typical of both HS and IBD, particularly when they coexist. However, this is still a largely unexplored field. PMID: 27239107 [PubMed - in process]
This study sought to evaluate the demographics, surgical procedures, bacteriology, pharmacologic intervention, and quality of life of patients with recalcitrant HS requiring surgical intervention. A retrospective chart review was performed of 76 recalcitrant HS patients at the University of Illinois Medical Center. Patient demographics, bacterial culture, and surgery data were reviewed. Quality of life was assessed using the 36-item short-form health survey. Patients were mostly female (73.7%) and African American (81.6%) with a mean duration of symptoms of 8.6 years before surgery. Patients underwent at least one surgical...