Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy

Publication date: Available online 21 February 2020Source: Chinese Chemical LettersAuthor(s): Lei Zhou, Chang Du, Rong Zhang, Changming DongAbstractWe developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous solution over 12.8―13.9 °C, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L D,L-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT-CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC50) of 2.23 µg/mL and a combination index of 0.36, displayinga superior synergistic effect between PTT and CCT in vitro.Graphical abstractThe dual anticancer drugs-conjugated PDOXCBs nanoparticles were facilely prepared by aqueous precipitation copolymerization of two dopamine prodrugs, which integrated intrinsic photothermia of PDA with the polyprodrug-induced cocktail chemotherapy for potentialcombination cancer PTT-CCTapplication.

Source: Chinese Chemical Letters - February 23, 2020 Category: Chemistry Source Type: research