Association between Plasma Dipeptidyl Peptidase-4 Activity to Brain-derived Neurotrophic Factor Ratio and Depressive Symptoms in Middle-Aged and Older Adults with Normal Glucose Tolerance: A Cross-Sectional Study.

Conclusions: Our data suggested inverse correlation between DPP4 activity and BDNF through the oxidative stress mediator. The positive relationship between DBR and depressive symptoms risk raise feasibility of identifying DBR as a novel biological marker or even a possible therapeutic target for depression.
PMID: 32081046 [PubMed - as supplied by publisher]

Source: The World Journal of Biological Psychiatry - February 20, 2020 Category: Psychiatry Authors: Zheng T, Chen X, Ge B, Chen B, Qin L, Tian L, Gao Y, Hu X, Xiao L, Pan H, Chen Y Tags: World J Biol Psychiatry Source Type: research