Bladder preservation in muscle-invasive bladder cancer: a comprehensive review

Conclusions This review highlights the breadth of strategies that aim to preserve a patient ’ s bladder while still optimizing local tumor control and overall survival. Future areas for innovation include the use of predictive biomarkers and implementation of immunotherapy, moving the field towards patient-tailored care.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research

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ABSTRACT Purpose To evaluate the influence of preoperative renal function on survival outcomes in patients who underwent radical cystectomy (RC) with non-continent urinary diversion (UD). Materials and Methods A total of 132 patients with bladder cancer who underwent RC with non-continent UD due to urothelial carcinoma from January 2006 toMarch 2017 at our tertiary referral center were retrospectively evaluated. Patients were divided into 2 groups as those with estimated glomerular filtration rate (eGFR)
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Authors: Su X, Tang Q, Fang D, Xiong G, Singla N, He Q, Zhang L, Liu P, Fan Y, Hao H, Li X, Zhou L Abstract The oncological outcomes of upper tract urothelial carcinoma (UTUC) and bladder cancer (BC) in patients treated with radical surgeries remains controversial. A retrospective analysis of the clinicopathologicla data of 228 consecutive UTUC patients and 174 BC patients treated with radical surgeries from 2000 to 2012 at a high-volume center in China was conducted. Kaplan-Meier method and Cox regression were used to compare overall survival (OS) and cancer-specific survival (CSS) and to find prognostic factors. ...
Source: International Journal of Clinical and Experimental Medicine - Category: Drugs & Pharmacology Tags: Int J Clin Exp Med Source Type: research
We present the case of a synchronous bilateral low-grade upper-tract urothelial carcinoma patient who underwent left nephroureterectomy and right total ureterectomy with ileal ureteric replacement resulting in a favorable prognosis. A 66-year-old male presented with bilateral hydronephrosis. Computed tomography revealed left pelvic and right upper –middle ureteral tumors with no lymph node swelling or distant metastasis. The patient underwent a left nephroureterectomy with a bladder cuff, and histopathology revealed a low-grade urothelial carcinoma. Considering the contralateral low-grade nature as revealed in histop...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
Authors: Ericson KJ, Murthy PB, Bryk DJ, Ramkumar RR, Broughman JR, Khanna A, Mian OY, Campbell SC Abstract Bladder-sparing therapies for the treatment of nonmetastatic muscle-invasive bladder cancers are included in both American and European guidelines. Numerous treatment approaches have been described, including partial cystectomy, radiation monotherapy, and radical transurethral resection. However, the most oncologically favorable and well-studied regimen employs a multimodal approach that consists of maximal transurethral resection of the bladder tumor followed by concurrent radiosensitizing chemotherapy and r...
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
Rationale: Radical cystectomy and urinary diversion remains the definite management for muscle invasive bladder urothelial cancer. Internal herniation caused by ureteral adhesion is an extremely rare complication after the procedure. To the best of our knowledge, this is the first case report of small bowel obstruction and internal herniation occurring between bilateral ureters and urinary diversion after robot-assisted radical cystectomy (RARC). Patient concerns: A 64-year-old woman presented with symptom of small bowel obstruction such as nausea, vomiting, and abdominal fullness after RARC and Indiana pouch. Another...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
AbstractUreteral metastases from other primary cancers are very rare. Treatment of these metastases is difficult and outcomes are poor. A thorough literature review was done with the aim of finding characteristics that may influence survival rates of patients with ureteral metastases. Systematic literature searches of PubMed and Web of Science were performed in Jan 2019. A total of 79 papers that included 265 patients with cancer metastases to their ureters were finally considered for evidence synthesis. Prostate, bladder, breast, gut cancer and lymphoma were the predominant primary tumors. The median interval time from pr...
Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research
This article details the methods and results of the main series available in the literature in terms of local control, survival, bladder preservation rates and complications, as well as study prospects. PMID: 31400955 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
CONCLUSIONS: Age, anesthetic risk, presence of hydronephrosis, pT and pN stage were identified as independent predictors of GM, as well as pT and pN stage for CSM. PMID: 31223123 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Publication date: Available online 7 May 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Dan Zhao, Bin Li, Yating Wang, Shuanghuan Liu, Yanan Zhang, Guangwen YuanABSTRACTStudy ObjectiveTo explore the feasibility of nerve plane–sparing laparoscopic radical hysterectomy (NPS-LRH) as a simplified C1-type surgery for cervical cancer patients and to compare this technique with laparoscopic radical hysterectomy (LRH).DesignA retrospective comparative study.SettingAn academic tertiary hospital affiliated with the Chinese National Cancer Center.PatientsSix hundred fifteen patients with Fédération...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
26Objectives: Radical cystectomy with urinary diversion is the Gold standard treatment for invasive muscle bladder cancer. A section of the bowel connected with ureters serves as a reservoir or conduit for urine. A stenosis of the uretero-ileal anastomosis might appear in 1:5 of patients. The identification of patients who would benefit from urological treatment is a significant clinical challenge. We proposed Diuresis-Renography (DR) gravity-assisted with method F+10(sp) (Seated Position), in the subset of patients with urinary diversion and a suspected stenosis of the urinary tract. Methods: 39 patients with CT or ultras...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: General Clinical Specialities: Renal/Hypertension Source Type: research
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