Exercise may ameliorate the detrimental side effects of high vitamin D supplementation on muscle function in mice

ABSTRACTVitamin D (VitD) is commonly prescribed to normalise deficiencies and to treat osteoporosis. However, the effect VitD supplements have on skeletal muscle health is equivocal. While VitD is known to play a role in the various processes that maintain muscle integrity and function, recent studies utilising high bolus dose VitD supplementation has demonstrated an increased risk of falls. Thus, the aim of this study was to investigate the effects of high VitD supplementation on skeletal muscle function with and without exercise enrichment. Four ‐week old C57BL/10 mice (n = 48) were separated into either normal VitD (1500 IU/kg diet; unsupplemented) or high VitD (20,000 IU/kg diet; supplemented) treatment groups. Each dietary group was further separated into interventional sub‐groups where mice either remained sedentary or receive d exercise‐enrichment for eight weeks in the form of voluntary running. Following the intervention period, whole bodyin vivo andex vivo contractile analysis were performed. High VitD supplementation decreased force production in the slow ‐twitch soleus muscles of sedentary mice (p 
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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Publication date: Available online 31 March 2020Source: Journal of OrthopaedicsAuthor(s): Athanasios N. Ververidis, Konstantinos Paraskevopoulos, Anthimos Keskinis, Nikolaos Adrianos Ververidis, Reichan Molla Moustafa, Konstantinos Tilkeridis
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
An artificial intelligence (AI) algorithm was able to assess a patient's risk...Read more on AuntMinnie.comRelated Reading: Could imaging AI research be endangering patients? New framework could support ethical data sharing for AI AI shows high accuracy for detecting COVID-19 on CT AI enables screening of fracture risk from CT scans AI accurately detects vertebral fractures on CT
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Background. Data on the prevention of fractures after heart transplant (HTx) are controversial in the literature. Understanding the effects of HTx on bone may guide appropriate treatments in this high-risk population. Methods. Seventy adult HTx patients were followed for 12 months. Clinical and laboratory parameters, bone mineral density, microarchitecture, and vertebral fractures were assessed at baseline (after intensive care unit discharge) and at 6 and 12 months. Patients received recommendations regarding calcium intake and vitamin D supplementation after HTx. Results. At baseline, 27% of patients had osteopor...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
AbstractAiming to uncover a shared genetic basis of abdominal obesity and osteoporosis, we performed a bivariate GWAS meta-analysis of femoral neck BMD (FNK-BMD) and trunk fat mass adjusted by trunk lean mass (TFMadj) in 11,496 subjects from 6 samples, followed by in silico replication in the large-scale UK Biobank (UKB) cohort. A series of functional investigations were conducted on the identified variants. Bivariate GWAS meta-analysis identified two novel pleiotropic loci 12q15 (lead SNPrs73134637,p = 3.45 × 10–7) and 10p14 (lead SNPrs2892347,p = 2.63 ×&t...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsThis analysis suggests that a screening programme of fracture risk in older women in the UK would gain quality of life and life years, and reduce fracture costs to more than offset the cost of running the programme.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ConclusionsConstitutive melanin density was associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults. This suggests melanin density either acts as a surrogate marker for an unmeasured fracture risk factor or the relationship between melanin density and fracture changes with time.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Lung transplant recipients have the highest rates of osteoporosis and fragility fractures of any solid organ transplant population. Several single nucleotide polymorphisms in genes important for bone metabolism have been identified. We hypothesized that risk alleles in these genes would be associated with decreased bone mineral density (BMD) following lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (460) Source Type: research
A 44-year-old woman with a history of hypertension and partial gastrectomy presented to the emergency department with low thoracic back pain of 2  days' duration without red flag symptoms. The physical examination was significant for point tenderness to palpation in the lower thoracic spine without overlying skin changes or neurologic symptoms. Considering her large body habitus and history of gastrectomy, a thoracic radiograph was obtained to rule out compression fracture due to osteoporosis (Figure 1).
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Visual Diagnosis in Emergency Medicine Source Type: research
AbstractPurpose of ReviewThe purpose is to review current literature on pain management strategies from initial presentation to postoperative care on common fracture types.Recent Findings- Hip fractures benefit from use of multimodal pain control for early mobility and decreased narcotic requirement.- Distal radius fracture pain during reduction can be managed with hematoma block. Postoperatively, a soft dressing is adequate, and use of a compression glove may improve pain control and edema.- Ankle fractures can be reduced with hematoma block, though use of procedural sedation may reduce reduction attempts for fracture dis...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
ABSTRACT Introduction: Use of androgen deprivation therapy (ADT) in carcinoma prostate (CaP) has deleterious effect on bone mineral density (BMD) leading to increase incidence of osteoporosis and skeletal-related events. We evaluated bone health status and impact of bone-directed therapy (BDT) and ADT on BMD in these patients from Jan 2015-Dec 2018. Materials and Method: Baseline bone health was assessed using Tc-99 MDP Bone scan/ DEXA scan for patients on ADT. Monthly zoledronic acid (ZA) was given to high-risk candidates (T-score ≤ 2.5 or previous hip/vertebral fracture) or Skel et al. metastatic patients who were rec...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
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