Radiation safety assessment of caregivers of thyroid cancer patients treated with 131I in Taiwan
In conclusion, as the dose rates at a 1-m distance from patients upon release were
CONCLUSIONS: In summary, by employing new long read sequencing methods, we were able to definitively demonstrate allele-specific DNA methylation, histone modifications, transcription factor binding, and the resulting mono-allelic transcription in cell lines with heterozygous TERT mutations. PMID: 32228178 [PubMed - as supplied by publisher]
CONCLUSIONS: The present study showed that specific RET-haplotypes, in particular haplotype 2 and the T-allele of p.Leu769=, are associated with a reduced risk of sMTC in Italians. PMID: 32228166 [PubMed - as supplied by publisher]
Authors: Lee YA, Im SW, Jung KC, Chung EJ, Shin CH, Kim JI, Park YJ Abstract Background Due to its very low prevalence, little is known about the genetic characteristics of pediatric follicular thyroid cancer (FTC). Methods We investigated genetic alterations in tumor tissues from 15 patients aged
CONCLUSIONS: Greater risk of BRAF-mutated papillary thyroid cancers among those with high BMI suggests that the association may not merely reflect greater healthcare service use and indicates an independent relationship between obesity and clinically important thyroid cancer. PMID: 32228152 [PubMed - as supplied by publisher]
CONCLUSION: Utilizing a large North American DTC registry, we found the prevalence of de novo TgAb detection to be 5% among initially TgAb negative patients. We did not find a statistically significant association between de novo TgAb development and DTC structural recurrence. Larger prospective studies are required to confirm these findings and further assess the significance of de novo TgAb detection in the follow up of DTC. PMID: 32228151 [PubMed - as supplied by publisher]
ConclusionsWe found a lower risk of radiation-induced secondary malignancies in LFS breast cancer patients than previously reported in the literature (33% risk of radiation-induced sarcoma). These findings suggest that LFS may not be an absolute contraindication for radiotherapy in breast cancer. The potential risk for locoregional recurrence without radiotherapy must be weighed against the long-term risk for radiation-induced malignancies in consideration of adjuvant radiotherapy for LFS breast cancer patients.
Publication date: Available online 31 March 2020Source: Pathology - Research and PracticeAuthor(s): Zhe-Jia Zhang, Qian Xiao, Xin-Ying Li
Conclusions: Several alterations in the plasma lipid metabolism were observed in the subclinical hyperthyroidism state that highlight the importance of this aspect in the follow-up of those patients. The increase in HDL-C and in the transfer of unesterified and esterified cholesterol to HDL, an important anti-atherogenic HDL function are consistently protective for cardiovascular health. The increase in Lp(a) and the decrease in PON-1 activity that are important risk factors were documented here in subclinical hyperthyroidism and these results should be confirmed in larger studies due to great data variation but should not...
AbstractIntroductionThe ATA guidelines for differentiated thyroid cancer (DTC) are one of the most widely referred to. Their 2015 edition proposed a new risk stratification system and modified the indications for radioactive iodine (RAI) ablation especially for the low risk category. We attempted to analyze whether the new guidelines altered referral practices for RAI ablation at our institute.MethodologyPatients who underwent total or completion thyroidectomy for DTC during 2016 –2017 were included. Relevant demographical and pathological data was tabulated. Patients were classified as per the new stratification sys...
CONCLUSION: Iodine-131-Caerin can inhibit the cell viability of thyroid cancer and hold certain promise as a theragnostic tool for human thyroid cancers. PMID: 32222729 [PubMed - as supplied by publisher]