Pharmacokinetics and tissue distribution in rats of a novel anticancer platinum compound LLC-1903.

Pharmacokinetics and tissue distribution in rats of a novel anticancer platinum compound LLC-1903. Xenobiotica. 2020 Feb 19;:1-8 Authors: Li Y, Meng F, Chen Z, Han F, He D, Hao Y, Gao A, Jiang J, Wang Z, Liu W, Liu Q Abstract LLC-1903, a novel anticancer compound, was synthesized by optimizing the structure, which was derived from altering the leaving group of lobaplatin. It has an excellent in vitro anti-cancer activity, high water solubility, high stability in solution and low in vivo toxicity according to our former study.The plasma pharmacokinetics (PK) and tissue distribution of LLC-1903 and lobaplatin in rats were determined after intravenous administration of a single dose (0.06 mmol/kg body weight). Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure the concentration of platinum (Pt) in plasma and tissue samples.Most PK parameters of the Pt in LLC-1903 showed a significant difference from those of lobaplatin. The plasma level of LLC-1903 is only half of that of lobaplatin (p < 0.01) which could be the direct result of faster drug clearance. The tissue distribution showed that both LLC-1903 and lobaplatin were mainly found in the liver and kidney, and less in other organs. At four time points (0.083, 0.5, 1 and 4 h) after administration, the tissue concentrations of LLC-1903 were almost always significantly higher than those of lobaplatin (p < 0.05 or p < 0.01). PMID: 3...
Source: Xenobiotica - Category: Research Authors: Tags: Xenobiotica Source Type: research