Glucocorticoid Metabolism in Obesity and Following Weight Loss

Glucocorticoids are steroid hormones produced by the adrenal cortex and are essential for the maintenance of various metabolic and homeostatic functions. Their function is regulated at the tissue level by 11β-hydroxysteroid dehydrogenases and they signal through the glucocorticoid receptor, a ligand-dependent transcription factor. Clinical observations have linked excess glucocorticoid levels with profound metabolic disturbances of intermediate metabolism resulting in abdominal obesity, insulin resistance and dyslipidaemia. In this review, we discuss the physiological mechanisms of glucocorticoid secretion, regulation and function, and survey the metabolic consequences of excess glucocorticoid action resulting from elevated release and activation or up-regulated signaling. Finally, we summarize the reported impact of weight loss by diet, exercise, or bariatric surgery on circulating and tissue-specific glucocorticoid levels and examine the therapeutic possibility of reversing glucocorticoid-associated metabolic disorders.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (572) Source Type: research
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Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (835) Source Type: research
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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Source: Health and Quality of Life Outcomes - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research
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Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
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Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
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Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Controversies in Bariatric Surgery Source Type: research
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Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: ASMBS Guidelines/Statements Source Type: research
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Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
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