Coronary Endothelial Dysfunction Prevented by SK Channel Activator in Mice and Patients with Diabetes

We investigated coronary endothelial protection of a small-conductance calcium-activated potassium (SK) channel activator against a period of cardioplegic-hypoxia and re-oxygenation (CP-H/R) injury in mice and patients with or without diabetes (DM).

Source: The Journal of Thoracic and Cardiovascular Surgery - February 18, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Zhiqi Zhang, Guangbin Shi, Yuhong Liu, Hang Xing, Anatoli Y. Kabakov, Amy S. Zhao;, Vahid Agbortoko, Justin Kim;, Arun K. Singh, Gideon Koren, Elizabeth O. Harrington, Frank W. Sellke, Jun Feng Source Type: research