Increased TGFα as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells.

CONCLUSIONS: These results suggest that overexpression of TGFα through induction of EGFR-MET interaction contributes to cetuximab resistance in CRC cells.
PMID: 24122793 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 11, 2013 Category: Cancer & Oncology Authors: Troiani T, Martinelli E, Napolitano S, Vitagliano D, Ciuffreda LP, Costantino S, Morgillo F, Capasso A, Sforza V, Nappi A, De Palma R, D'aiuto E, Berrino L, Bianco R, Ciardiello F Tags: Clin Cancer Res Source Type: research