The structure of the oxidized state of cytochrome c oxidase - experiments and theory compared.

The structure of the oxidized state of cytochrome c oxidase - experiments and theory compared. J Inorg Biochem. 2020 Feb 08;206:111020 Authors: Blomberg MRA Abstract Cytochrome c oxidase (CcO), the terminal enzyme in the respiratory chain, reduces molecular oxygen to water. Experimental data on the midpoint potentials of the heme iron/copper active site cofactors do not match the overall reaction energetics, and are also in conflict with the observed efficiency of energy conservation in CcO. Therefore it has been postulated that the ferric/cupric intermediate (the oxidized state) exists in two forms. One form, labelled OH, is presumably involved during catalytic turnover, and should have a high CuB midpoint potential due to a metastable high energy structure. When no more electrons are supplied, the OH state supposedly relaxes to the resting form, labelled O, with a lower energy and a lower midpoint potential. It has been suggested that there is a pure geometrical difference between the OH and O states, obtained by moving a water molecule inside the active site. It is shown here that the difference between the two forms of the oxidized state must be of a more chemical nature. The reason is that all types of geometrically relaxed structures of the oxidized intermediate have similar energies, all with a high proton coupled reduction potential in accordance with the postulated OH state. One hypothesized chemical modification of the OH state is the transfer ...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research

Related Links:

No abstract available
Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: NACNS News Source Type: research
No abstract available
Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: Editorial Source Type: research
No abstract available
Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: Legal and Ethical Source Type: research
No abstract available
Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: Nurse Entrepreneur Source Type: research
Conclusions Similar to other childhood-onset conditions, adolescents and young adults with OI require education and mentorship, and clinicians in the adult healthcare system need to be prepared and supported to receive them. Collective efforts are needed to improve the self-management and transitional care needs for young adults with OI.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
Conclusions The results of this study highlight the key role that expert nurses play in the care of patients with DFS. Expert nurses considered that amputation leaves the individual physically and psychologically vulnerable, especially upon discharge from hospital. It is therefore essential to provide these patients with comprehensive and multidisciplinary care that includes emotional support.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
Conclusion Although emergency department naloxone distribution programs are feasible in the acute care setting, it was critical for clinical nurse specialists to enlist an interdisciplinary team and engage executive leadership to ensure program success. For others considering such a program, early consideration should be given to determining financial support and evaluating the compliance and regulatory aspects of dispensing medications from emergency settings.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
Conclusion The findings provide strategies that can be used to prepare graduate nurses to work in data science teams to shape big data research and optimize patient outcomes.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
Conclusions A larger educational research study to test the effect of this education on improving nursing confidence and offering the mirror is recommended.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
No abstract available
Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: Nursing and the Arts Source Type: research
More News: Biochemistry | Chemistry | Copper | Iron | Respiratory Medicine