Canagliflozin inhibits p-gp function and early autophagy and improves the sensitivity to the antitumor effect of doxorubicin.

This study is the first to report that a classical antidiabetic drug, CAN improved the sensitivity to the antitumor effect of DOX, and the potential molecular mechanisms of CAN may involve the inhibition of P-gp function and the autophagy pathway. PMID: 32061772 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32061772?dopt=Abstract

Source: Biochemical Pharmacology - February 12, 2020 Category: Drugs & Pharmacology Authors: Zhong J, Sun P, Xu N, Liao M, Xu C, Ding Y, Cai J, Zhang Y, Xie W Tags: Biochem Pharmacol Source Type: research