Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease
This pooled cohort involving US adults with white European ancestry compares the accuracy of a polygenic risk score vs 2013 ACC/AHA pooled cohort equations for predicting 10-year risk of coronary heart disease.
Reduced expression of the key regulator of cardiac metabolism, transcription factor PPAR α, in surgical samples of the auricles from patients with coronary heart disease and heart failure was detected by real-time quantitative PCR. These changes indicate reduced activity of this factor and a shift of energy metabolism from oxidative phosphorylation to glycolysis typical of dedifferenti ated cells. Electron microscopy revealed dedifferentiated cardiomyocytes with disassembled contractile apparatus and disorganized sarcomeres. In the examined specimens from patients with heart failure, severe myocardial fibrosis was revealed.
CONCLUSION: Current data imply that PCI for CCS does not improve outcomes in a large percentage of cases. A symptomatic benefit exists only in patients with frequent angina pectoris. The selection of CCS patients for PCI needs to be more strictly bound to the recommendations of current guidelines, particularly in Germany. PMID: 32234189 [PubMed - in process]
Conclusion: Amlodipine lowered long-term gout risk compared with lisinopril or chlorthalidone. This finding may be useful in cases where gout risk is a principal concern among patients being treated for hypertension. This trial is registered at clinicaltrials.gov, number: NCT00000542.
CONCLUSIONS: In this depictive study of 85 fatal cases of COVID-19, most cases were male aged over 50 years old with noncommunicable chronic diseases. The majority of the patients died of multiple organ failure. Early onset of shortness of breath may be used as an observational symptom for COVID-19 exacerbations. Eosinophilopenia may indicate a poor prognosis. The combination of anti-microbial drugs did not offer considerable benefit to the outcome of this group of patients. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://crea...
Conventional risk factors for stroke that have been identified are mostly chronic diseases that explain much of the variation as to who develops stroke. However, these risk factors do not equip us with the means to predict when an event like stroke will occur. It has been observed that acute events like stroke and coronary heart disease are preceded by episodes of acute stress. The present study was undertaken to determine whether acute psychological stress is a potential triggering factor for the occurrence of stroke.
CONCLUSION: The impact of the EUROACTION intervention on lifestyle and CVD risk factors could have contributed to lower mortality in INT coronary and high risk patients. These results emphasise the need for sustaining the interventions to help patients maintain a healthy life style. PMID: 32238795 [PubMed - as supplied by publisher]
The protective effect of cardiorespiratory fitness on vascular outcomes including sudden cardiac death (SCD) is well established.1-3 Emerging evidence suggests that handgrip strength (HGS), a typical measure of muscular strength, is prospectively and inversely associated with mortality and vascular outcomes such as cardiovascular disease (CVD), coronary heart disease (CHD), and heart failure.4-6 Given the relationship between HGS and vascular outcomes, we hypothesized that HGS would be linked to the risk of SCD.
To investigate the contribution of individual and population factors to Coronary Heart Disease (CHD) mortality rates in Ireland between 2000 and 2015.
Tobacco smoking is one of the most important risk factors of coronary heart disease (CHD). Hence, smoking cessation is considered pivotal in the prevention of CHD. The current study aimed to evaluate smoking c...