Zoonotic Virus Linked to Severe Encephalitis in Southern Germany

A recent study suggested that Borna disease virus 1 (BoDV-1), which is carried by wild shrews in Germany, Austria, Switzerland, and Liechtenstein, could be a more common cause of severe or fatal encephalitis among people in endemic areas than previously realized.
Source: JAMA - Category: General Medicine Source Type: research

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Brucellosis is a common zoonotic infection caused by bacterial genusBrucella, a Gram ‑negative bacterium, and continued to be a health problem in endemic areas. Anti ‑N‑methyl‑d‑aspartate receptor (NMDAR) encephalitis is an autoimmune disease which can lead to status epilepticus.  A 19 ‑year‑old male patient was referred to our hospital with status epilepticus. The diagnosis ofbrucellosis was confirmed about 2 weeks before.The brain magnetic resonance imaging was  normal. Lumbar puncture was performed, and cerebral spinal fluid (CSF) was in normal limits. The  patient was treated with...
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
In this study, interleukin enhancer-binding factor 2 (ILF2) is identified as a novel cellular protein interacting with NS3 through co-immunoprecipitation assay and LC-MS/MS. The expression of ILF2 is decreased in JEV-infected human embryonic kidney (293T) cells. The knockdown of endogenous ILF2 by special short hairpin RNA (shRNA) positively regulates JEV propagation, whereas the overexpression of ILF2 results in a significantly reduced JEV genome synthesis. Further analysis revealed that the knockdown of ILF2 positively regulates viral replication by JEV replicon system studies. These results suggest that ILF2 may act as ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Tiphany Chrun1,2*, Sandra Lacôte2, Céline Urien1, Charles-Adrien Richard1, Matthias Tenbusch3, Nicolas Aubrey4, Coralie Pulido5, Latifa Lakhdar5, Philippe Marianneau2* and Isabelle Schwartz-Cornil1* 1VIM-INRA-Université Paris-Saclay, Jouy-en-Josas, France2ANSES-Laboratoire de Lyon, Unité Virologie, Lyon, France3Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Medical Immunology Campus Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany4ISP, INRA, Université de Tours, UMR 1282 Team BioMAP, Nouzilly, F...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators. Given...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Ruchika Tandon, Amit Kumar, Ajay KumarAnnals of Indian Academy of Neurology 2019 22(2):237-240 Scrub typhus, a mite-borne zoonotic disease, is endemic in several parts of India. It may cause multisystemic disease involving lungs, heart, spleen, liver, hematological system, and nervous system. Neurological involvement may include meningoencephalitis, cerebellitis, cranial nerve palsies, plexopathy, transverse myelitis, muscle dysfunction, neuroleptic malignant syndrome, parkinsonian syndrome, and Guillain–Barre syndrome. Here, we report a rare patient of scrub typhus, who developed meningoencephalitis followed by lon...
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
This study was aimed to investigate the prevalence of JEV in mosquitoes and humans in the Thanjavur district, a non-endemic region for JE, in Tamil Nadu, by using standard available assays. Methods: : A sero-surveillance study was conducted in Thanjavur district among the normal rural school children in the 5-12 yr age group, during the JE season (October) and post-JE season (February) from 2011 to 2013 for the detection of JEV infection. Vector abundance studies were carried out from 2011 to 2014. JE seropositivity and its association between the seasons were analysed statistically. Results: : The occurrence of JE...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
We report the clinical and radiological findings of eight patients with laboratory-confirmed rabies who survived the illness. With the exception of one patient who recovered with mild sequelae, all survivors had poor functional outcomes. The reported survival from rabies in recent years may reflect an increased awareness of the disease and greater access to better critical care facilities in rabies-endemic countries. Nonetheless, there is an urgent need to focus on preventive strategies to reduce the burden of this dreadful disease in rabies-endemic countries. PMID: 30398147 [PubMed - as supplied by publisher]
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Publication date: 7 October 2018Source: Journal of Theoretical Biology, Volume 454Author(s): Shi Zhao, Yijun Lou, Alice P.Y. Chiu, Daihai HeAbstractJapanese encephalitis virus (JEV) is a zoonotic mosquito-borne virus, persisting in pigs, Ardeid birds and Culex mosquitoes. It is endemic to China and Southeastern Asia. The case-fatality ratio (CFR) or the rate of permanent psychiatric sequelae is 30% among symptomatic patients. There were no reported local JEV human cases between 2006 and 2010 in Hong Kong, but it was followed by a resurgence of cases from 2011 to 2017. The mechanism behind this “skip-and-resurgence&rd...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
In this study, a μ-capture ELISA was developed to detect TBEV-specific IgM antibodies using subviral particles (SPs) with strep-tag (strep-SP-IgM-ELISA). The results of our strep-SP-IgM-ELISA were highly correlated with diagnoses made by the neutralization test (sensitivity: 94.1%), and our strep-SP-IgM-ELISA could detect anti-TBEV IgM antibodies in patients who could not be diagnosed with the neutralization test. Besides, 51 of 52 positive samples by a commercial IgM-ELISA were also diagnosed as positive by our strep-SP-IgM-ELISA (98.1%), and our strep-SP-IgM-ELISA could detect anti-TBEV IgM antibodies in all samples t...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: 7 October 2018Source: Journal of Theoretical Biology, Volume 454Author(s): Shi Zhao, Yijun Lou, Alice P.Y. Chiu, Daihai HeAbstractJapanese encephalitis virus (JEV) is a zoonotic mosquito-borne virus, persisting in pigs, Ardeid birds and Culex mosquitoes. It is endemic to China and Southeastern Asia. The case-fatality ratio (CFR) or the rate of permanent psychiatric sequelae is 30% among symptomatic patients. There were no reported local JEV human cases between 2006 and 2010 in Hong Kong, but it was followed by a resurgence of cases from 2011 to 2017. The mechanism behind this “skip-and-resurgence&rd...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
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