These are the states with the highest risk for melanoma linked to UV rays
States with the highest rates of melanoma cases linked to ultraviolet radiation are spread across the United States on the East and West coasts, in Hawaii and in landlocked states, according to a study published Monday in the International Journal of Cancer.
Conditions: Non-melanoma Skin Cancer; Melanoma; Hypertension Interventions: Drug: Hydrochlorothiazide; Drug: Angiotensin-converting enzyme (ACE) inhibitors Sponsors: Canadian Network for Observational Drug Effect Studies, CNODES; Drug Safety and Effectiveness Network, Canada; Canadian Institutes of Health Research (CIHR) Active, not recruiting
Photochem. Photobiol. Sci., 2020, Advance Article DOI: 10.1039/C9PP00284G, PaperFl ávia Amanda Pedroso de Morais, Renato Sonchini Gonçalves, Bruno Henrique Vilsinski, Danielle Lazarin-Bidóia, Rodolfo Bento Balbinot, Tayana Mazin Tsubone, Kellen Brunaldi, Celso Vatatu Nakamura, Noboru Hioka, Wilker Caetano The Hyp/DPPC formulation photodynamic effect in melanoma B16-F10 cells pointed out its potentiality for PDT against cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Contributors : M Georganaki ; M Ramachandran ; S Tuit ; N Nunez ; A Karampatzakis ; G Fotaki ; L van Hooren ; H Huang ; R Lugano ; T Ulas ; A Kaunisto ; E Holland ; P Ellmark ; S M Mangsbo ; J L Schultze ; M Essand ; S Tugues ; A DimbergSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD40-stimulating immunotherapy elicits potent anti-tumor responses, which are mainly T-cell dependent. Here, we have investigated how tumor endothelial cells respond to CD40-stimulating immunotherapy by isolating endothelial cells from B16.F10 melanoma in anti-CD40 treated or isotype treated mice followed...
ConclusionsCurrent clinical trials are exploring combination therapy and novel treatment strategies beyond immune checkpoint therapies and vaccine therapy such as CAR T cells. There is also an effort to establish synergy between immunotherapy and current standard of care. Furthermore, recent advances in personalized neoantigen vaccines suggest a shift towards personalized, patient-specific GBM treatment.
ConclusionIn MBM patients, complications after GKRS are not significantly increased if IT/TT treatment is performed at the time of or after radiosurgery. Further, a clear benefit in distant control and survival is seen in MBM patients treated with GKRS and checkpoint inhibitors. Thus, concomitant treatment of MBM with GKRS and IT/TT seems to be a safe and powerful treatment option although further prospective studies should be conducted.
CONCLUSIONS: Neurological involvement in MM encompasses a myriad of variants and while the clinical setting varies from one patient to another, an underlining neoplasia should be evaluated in suspected patients. PMID: 32239096 [PubMed - in process]
Matrix metalloproteinases expression in lentigo maligna∕lentigo maligna melanoma - a review of the literature and personal experience. Rom J Morphol Embryol. 2019;60(4):1091-1095 Authors: Brînzea A, Nedelcu RI, Ion DA, Turcu G, Antohe M, Hodorogea A, Călinescu A, Pirici D, Popescu R, Popescu CM, Popp CG, Nichita L, Cioplea MD, Cordun M, Zurac SA Abstract Cutaneous melanoma is the most aggressive type of skin cancer, with high invasive potential. Lentigo maligna melanoma (LMM) is a relatively rare type, accounting for about 10% of all melanomas, while the most common subtype of melanoma on the ...
ConclusionsImmunosuppressed patients who develop melanoma have worse outcomes when matched to non-immunosuppressed patients. This decrease in survival appears related to the underlying condition rather than diagnosis of melanoma.
Immunotherapies harnessing T cell immunity have shown remarkable clinical success for the management of cancer. However, only a proportion of patients benefit from these treatments. The presence of type I interferon (IFN) within the tumor microenvironment is critical for driving effective tumor-specific T cell immunity. Individuals can produce 12 distinct subtypes of IFNα, which all signal through a common receptor. Despite reported differences in anti-viral potencies, the concept that distinct IFNα subtypes can improve anti-cancer treatments remains unclear. We tested whether expression of unique IFNα su...
ConclusionsResveratrol could synergistically enhance the killing effect of TK/GCV suicide gene system in melanoma B16 cells and transplanted melanoma. It might be a promising adjuvant of TK/GCV therapy.