Management of dementia-related psychosis, agitation and aggression: a review of the pharmacology and clinical effects of potential drug candidates - Marcinkowska M, Śniecikowska J, Fajkis N, Paśko P, Franczyk W, Kołaczkowski M.

Along with cognitive decline, 90% of patients with dementia experience behavioral and psychological symptoms of dementia, such as psychosis, aggression, agitation, and depression. Atypical antipsychotics are commonly prescribed off-label to manage certain ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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CONCLUSIONS: Neurodegenerative disease should be on the differential diagnosis for any patient presenting with new-onset psychosis and behavioral changes in mid to late adulthood. Should red-flag features be present, early referral to a clinic specializing in dementia is recommended for further evaluation. This case highlights that MAPT mutations can be associated with psychosis in FTD and should be considered in the genetic workup. Ongoing research into the cellular and neural circuit mechanisms of psychosis in neurodegenerative disease may shed light on pathologic processes underlying psychosis in primary psychiatric dis...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Mrs. S is an 85-year-old woman who moved into the nursing home five years ago when her husband could no longer provide care for her due to her progressive weakness and failure to thrive. She has a history of Barrett ’s esophagus and significant reflux and subsequent dysphagia, a long history of depression, allergic rhinitis, dementia with a Brief Interview for Mental Status (BIMS) score of 12, basal cell carcinoma, insomnia, iron deficiency anemia, and a pneumonitis due to aspiration. She is oxygen dependent.
Source: Caring for the Ages - Category: Health Management Authors: Tags: Interdisciplinary Team Case Studies Source Type: news
__ Data for Good: Biological Scientist, DSI Member Rafael Yuste on the Ethical Development of Neurotechnology (Columbia University release): “Brain-computer interfaces may soon have the power to decode people’s thoughts and interfere with their mental activity. Even now the interfaces, or BCIs, which link brains directly to digital networks, are helping brain-impaired patients and amputees perform simple motor tasks such as moving a cursor, controlling a motorized wheelchair, or directing a robotic arm. And noninvasive BCI’s that can understand words we want to type and place them onto screens are being d...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Algorithmic Bias Brain-Computer Interfaces free-will Mental Augmentation mental privacy neurorights neurotechnologies Neurotechnology oath Personal Identity Rafael Yuste techn Source Type: blogs
This study aimed to investigate the occurrence of suicidal ideation and associated factors in older persons with dementia living at home in eight European countries, and its association with quality of life. Furthermore, changes in suicidal ideation over time were investigated.Methods: This cohort study (n = 1,223) was part of the European "RightTimePlaceCare" project conducted in 2010-2013. Participating countries were Estonia, Finland, France, Germany, the Netherlands, Spain, Sweden and the United Kingdom. Baseline and follow-up data were analysed using bivariate and multivariate logistic regressi...
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
__ Time for a new edition of SharpBrains’ e‑newsletter, featuring this time 14 timely news and resources for mental health and brain health innovation. First of all, let’s remain safe, healthy, and centered during the current health crisis by following these tips provided by the Greater Good Science Center at UC Berkeley: 1. Stay calm and focused 2. Pay attention to those doing the right thing 3. Show gratitude 4. Remember our common bonds 1) “Of course, all of these guidelines don’t supplant the importance of practicing good hygiene. We need to continue to frequently wash our hands and avoid...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology adhd brain brain health Brain Teasers brain-functions chronic pain coronavirus outbreak cross-train the brain dementia innovation LivaNova Medt Source Type: blogs
It is increasingly recognized that there is significant heterogeneity in phenotype and clinical trajectories in Alzheimer's disease as well as Lewy Body and Vascular dementia. Relatively common neurodegenerative disorder, Lewy Body Dementia (LBD) presents with psychiatric features. Mood disorders are common and often precede core symptoms of LBD. Patient with LBD especially early in the course of disease are at increased risk for suicide. Psychosis is one of the most debilitating symptoms of LBD as it is an independent risk factor for nursing home placements, increased caregiver distress and mortality.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Session 304 Source Type: research
Matters of the Mind offers an occasional look at recent research into the relationship between the mind and the body.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Journalist and filmmaker Max Lugavere has committed his life to exploring and understanding brain health, prompted by the loss of his mom to dementia that began at the unusually young age of 58. His newest book, Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary, has just been released. Written with genuine heartfelt passion and attention to detail, Max has crafted a wonderful book for anyone interested in understanding how to preserve brain health and bolster brain performance. Here is an excerpt from the especially well-crafted chapter he calls “The Vigor Trigger”: Ice, Ice, Baby Prio...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open avoid cognitive decline brain health can Alzheimers be prevented can dementia be prevented cognition lugavere preserve cognition prevent Alzheimers prevent dementia Source Type: blogs
AbstractPurpose of ReviewDementia is a progressive brain disease that affects 5.8 million people in the USA. In 2018, more than 16 million Americans provided unpaid care for persons with dementia (PWD). Most of this care is provided by family members and friends yielding 18.5 billion hours of unpaid care worth $233.9 billion.Novel technological approaches to assist caregivers and improve health and function of PWD are being explored. Models to assess and predict behaviors may provide greater quality of life (QOL) for both PWD and their caregivers. The purpose of this paper is to review current available technologies for be...
Source: Current Geriatrics Reports - Category: Geriatrics Source Type: research
Photo credit Berhard Grossgasteiger The truth, as they see it, is still the truth in their eyes. Delusions, hallucinations, agitation, aggression, and depression are all part of the gradual progression of psychosis of patients with Alzheimer ’s disease (AD). An average of 41% of these patients will experience these psychotic symptoms. One of the most common delusions these patients have is theft-related. An experienced caregiver offers her advice on how to deal with accusations of theft, which are common in dementia patients. Continue reading on Agingcare to learn more about the frustration and pain of being falsely ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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