Tumor-Treating Field Arrays Do Not Reduce Target Volume Coverage for Glioblastoma Radiation Therapy.
ConclusionsThese findings point to a novel immunologic mechanism underlying the interaction between radiotherapy and immunotherapy. They also provide the basis for clinical investigation of immunogenic dose radiation in combination with immune checkpoint blockade as a potential treatment approach for newly diagnosed high grade gliomas.
An acoustic neuroma, also known as a vestibular schwannoma, is a tumor of the hearing and balance nerve complex in the brain. They are rare, and account for less than 10% of all brain tumors. The tumor involves an area of the brain and ear called the lateral skull base; an acoustic neuroma can range in size, and it can cause a variety of troublesome symptoms related to hearing and balance. It is important to note that although the diagnosis of a brain tumor can cause significant anxiety, acoustic neuromas are noncancerous and grow very slowly. This means that immediate treatment is rarely necessary. What are the most commo...
Conditions: Brain Tumor; Cognitive Impairment; Radiation Toxicity Intervention: Other: Cognitive tests and Patient Reported Outcome Sponsor: University of Aarhus Recruiting
Brock Fuller Chung Glioblastoma is an aggressive brain tumor with a propensity for intracranial recurrence. We hypothesized that tumors can be visualized with diffusion tensor imaging (DTI) before they are detected on anatomical magnetic resonance (MR) images. We retrospectively analyzed serial MR images from 30 patients, including the DTI and T1-weighted images at recurrence, at 2 months and 4 months before recurrence, and at 1 month after radiation therapy. The diffusion maps and T1 images were deformably registered longitudinally. The recurrent tumor was manually segmented on the T1-weighted image and then app...
Conclusion: In future investigations, focusing on the genetic basis of the glioma patients in line with imaging studies on a larger sample size, which is known as genetics imaging, would be a suitable approach for tracing this process.
Synchrotron microbeam radiation therapy (MRT) is based on the spatial fractionation of the incident, highly collimated synchrotron beam into arrays of parallel microbeams depositing several hundred grays. It appears relevant to combine MRT with a conventional treatment course, preparing a treatment scheme for future patients in clinical trials. The efficiency of MRT delivered after several broad beam (BB) fractions to palliate of F98 brain tumors in rats in comparison with BB fractions alone was evaluated in this study.
Conclusions: Parents of children treated for BT report widespread and persistent deficits in executive functions that negatively affect their everyday functioning. Including analysis of all clinical scales and composite indices allows a more comprehensive approach and enables to specify the patients' executive profile. PMID: 32050813 [PubMed - as supplied by publisher]