Furin cleavage site in the SARS-CoV-2 coronavirus glycoprotein

The spike glycoprotein of the newly emerged SARS-CoV-2 contains a potential cleavage site for furin proteases. This observation has implications for the zoonotic origin of the virus and its epidemic spread in China. The membrane of coronaviruses harbors a trimeric transmembrane spike (S) glycoprotein (pictured) which is essential for entry of virus particles into the […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information bat coronavirus COVID-19 epidemic furin SARS-CoV-2019 spike glycoprotein viral viruses Wuhan zoonosis Source Type: blogs

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In conclusion, the present study revealed that the upregulation of RBM47 accelerated the malignant progression of NSCLC, indicating that RBM47 may be a potential biomarker for NSCLC progression and a therapeutic target for NSCLC. PMID: 32218862 [PubMed - as supplied by publisher]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Kang Y, Cui Y, Tan M Abstract Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck that is prevalent in China. The present study investigated the molecular mechanisms of microRNA-212 (miR-212) and E74-like factor 3 (ELF3) in NPC cell lines and tissues. Using reverse transcription-quantitative PCR, the present study identified that miR-212 expression was downregulated in NPC cell lines and tissues. Furthermore, an elevated expression level of miR-212 was revealed to inhibit NPC cell proliferation, as determined using a cell counting kit-8 assay in vitro. ELF3 was identified as a d...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Wang QS, Wei SR, Xiao HL Abstract Lung cancer is the most common cause of cancer-associated mortality in China with 85% of patients having non-small cell lung cancer (NSCLC). Identifying NSCLC driver genes and prognostic markers is critical to reducing these numbers. The studies of retinoblastoma binding protein 6 (RBBP6) performed on NSCLC is limited. The present study aimed to investigate the molecular function and the prognostic potential of RBBP6 in NSCLC using the A549 cell line and patient samples, respectively. The functional effect on cancer cell proliferation and prognostic value of RBBP6 were exa...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, CCL14 is an independent prognostic factor for EOC and upregulation of CCL14 is associated with a more favorable prognosis in patients with EOC. PMID: 32218842 [PubMed - as supplied by publisher]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 29 March 2020Source: LWTAuthor(s): Biao Suo, Wenjing Nie, Yuexia Wang, Jingyi Ma, Xiaolong Xing, Zhongmin Huang, Chao Xu, Zhen Li, Zhilu Ai
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Citing concerns about the COVID-19 pandemic, Aurora Health Care is postponing the opening of its $130 million clinic, ambulatory surgery center and physician office building in Pleasant Prairie. The Pleasant Prairie facility is the first major health care project in southeast Wisconsin announced as delayed by COVID-19 challenges in the health care industry. Aurora Health Care didn’t immediately respond to questions seeking more details on the reasons for the decision. However, parent company…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
[Premium Times] President Muhammadu Buhari will address Nigerians on Sunday by 7:00 p.m., his office has said, amidst criticisms by many Nigerians over his failure to address the country since the COVID-19 pandemic broke.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 4 February 2020Source: Microbes and InfectionAuthor(s): Jieliang ChenAbstractA zoonotic coronavirus, labeled as 2019-nCoV by The World Health Organization (WHO), has been identified as the causative agent of the viral pneumonia outbreak in Wuhan, China, at the end of 2019. Although 2019-nCoV can cause a severe respiratory illness like SARS and MERS, evidence from clinics suggested that 2019-nCoV is generally less pathogenic than SARS-CoV, and much less than MERS-CoV. The transmissibility of 2019-nCoV is still debated and needs to be further assessed. To avoid the 2019-nCoV outbreak turnin...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
On 31 December 2019 the Wuhan Health Commission reported a cluster of atypical pneumonia cases that was linked to a wet market in the city of Wuhan, China. The first patients began experiencing symptoms of illness in mid-December 2019. Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. As of 28 January 2020, there are in excess of 4,500 laboratory-confirmed cases, with> 100 known deaths. As with the SARS-CoV, infections in children appear to be rare. Travel-related cases have been confirmed in multiple countries and regions outside mainland China including Germany, France, ...
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
Authors: Azhar EI, Lanini S, Ippolito G, Zumla A Abstract Two new zoonotic coronaviruses causing disease in humans (Zumla et al. 2015a; Hui and Zumla 2015; Peiris et al. 2003; Yu et al. 2014) have been the focus of international attention for the past 14 years due to their epidemic potential; (1) The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) (Peiris et al. 2003) first discovered in China in 2001 caused a major global epidemic of the Severe Acute Respiratory Syndrome (SARS). (2) The Middle East respiratory syndrome coronavirus (MERS-CoV) is a new corona virus isolated for the first time in a pati...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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