Ethyl Pyruvate Protects against Blood-Brain Barrier Damage and Improves Long-term Neurological Outcomes in a Rat Model of Traumatic Brain Injury.

CONCLUSION: Ethyl pyruvate confers long-term neuroprotection against TBI, possibly through breaking the vicious cycle among MMP-9-mediated BBB disruption, neuroinflammation, and long-lasting brain damage.
PMID: 25533312 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - December 23, 2014 Category: Neuroscience Authors: Shi H, Wang H, Pu H, Shi Y, Zhang J, Zhang W, Wang G, Hu X, Leak RK, Chen J, Gao Y Tags: CNS Neurosci Ther Source Type: research