Synthesis, Characterisation and Crystal Structure of a new Cu(II)-Carboxamide Complex and CuO Nanoparticles as new Catalysts in the CuAAC Reaction and Investigation of their Antibacterial Activity

Publication date: Available online 12 February 2020Source: Inorganica Chimica ActaAuthor(s): Mahsa Kiani, Mojtaba Bagherzadeh, Soraya Meghdadi, Farzaneh Fadaei-Tirani, Maryam Babaie, Kurt Schenk-JoßAbstractThe bidentate carboxamide ligand N-(thiazole-2-yl) picolinamide (LH) was synthesized in the environmentally friendly ionic liquid TBAB, and the five-coordinated CuII-complex, [Cu(L)2(H2O)].CHCl3 (1) was synthesized from LH and copper(II)acetate. Cupric oxide [CuO] nanoparticles (2) have been prepared by the thermal decomposition of (1) as a new precursor at 600°C for 3 h under air atmosphere. (1) was characterised using FT-IR spectroscopy, elemental analyses and its solid state structure was confirmed by single crystal X-ray diffraction. (2) were identified by FT-IR spectroscopy, X-ray powder diffraction, scanning electron microscopy, energy dispersive X-ray analysis and thermo-gravimetric differential thermal analyses. The electrochemical behaviour of LH and (1) has been investigated by cyclic voltammetry: irreversible CuII/I reductions were observed. The catalytic activity of (1) and (2) were evaluated in the one-pot azide–alkyne cycloaddition click reaction in water without additional agents. LH, (1) and (2) were also screened for their in vitro antibacterial activity: they showed promising antibacterial activity comparable to that of the antibiotic penicillin.Graphical abstract
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research