Urocortin 2 is associated with abdominal aortic aneurysm and mediates anti-proliferative effects on vascular smooth muscle cells via corticotrophin releasing factor receptor 2

In conclusion, UCN2 is significantly associated with AAA and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA pathogenesis.

Source: Clinical Science - October 10, 2013 Category: Biomedical Science Authors: T I Emeto, J V Moxon, E Biros, C M Rush, P Clancy, L Woodward, C S Moran, R J Jose, T Nguyen, P J Walker, J Golledge Source Type: research