IL-4 controls activated neutrophil Fc{gamma}R2b expression and migration into inflamed ȷoints [Immunology and Inflammation]

Neutrophils are the most abundant immune cells found in actively inflamed joints of patients with rheumatoid arthritis (RA), and most animal models for RA depend on neutrophils for the induction of joint inflammation. Exogenous IL-4 and IL-13 protect mice from antibody-mediated joint inflammation, although the mechanism is not understood. Neutrophils...

Source: Proceedings of the National Academy of Sciences - February 10, 2020 Category: Science Authors: Sudeepta Kumar Panda, Gustaf Wigerblad, Long Jiang, Yanek Jimenez–Andrade, Vaishnavi Srinivasan Iyer, Yunbing Shen, Sanȷaykumar V. Boddul, Andre Ortlieb Guerreiro–Cacais, Bruno Raposo, Zsolt Kasza, Fredrik Wermeling Tags: Biological Sciences Source Type: research