IP-10/CXCR3 axis is associated with HHV-6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms.

CONCLUSIONS: Higher plasma IP-10 levels are associated with the development of long-term sequelae in DRESS. Higher IP-10/CXCR3 expression in skin and more abundant CLA+ CXCR3+ CD4+ cells and CLA+ CXCR3+ CD8+ cells were observed in DRESS patients with HHV-6 reactivation. The IP-10/CXCR3 axis is associated with HHV-6 reactivation and development of long-term sequelae in DRESS. PMID: 32037509 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32037509?dopt=Abstract

Source: The British Journal of Dermatology - February 8, 2020 Category: Dermatology Authors: Yang CW, Cho YT, Hsieh YC, Hsu SH, Chen KL, Chu CY Tags: Br J Dermatol Source Type: research