Mild sleep restriction increases 24-hour ambulatory blood pressure in pre-menopausal women with no indication of mediation by psychological effects

Publication date: Available online 8 February 2020Source: American Heart JournalAuthor(s): Marie-Pierre St-Onge, Ayanna Campbell, Brooke Aggarwal, Jasmine L. Taylor, Tanya M. Spruill, Arindam RoyChoudhuryAbstractStudies assessing the impact of sleep restriction (SR) on blood pressure (BP) are limited by short study length, extreme SR (<4 h/night), and lack of attention to psychological distress as a possible mediator. A community-based cohort was assembled with 237 women (age 34.1 ± 13.5y; BMI 25.4 ± 5.4 kg/m2) and a randomized, crossover, intervention study was conducted in 41 women (24 completed: age 30.2 ± 6.5y; BMI 24.3 ± 2.8 kg/m2) to determine the causal effect of SR on BP. Sleep was maintained as usual (HS) or reduced by 1.5 h/night (SR) for 6wk. In the cohort, associations between sleep and psychosocial factors were evaluated using multivariable models adjusted for demographic and clinical confounders. In the intervention study, in-office BP was measured weekly; ambulatory BP was measured at endpoint. Psychological factors were assessed at baseline and endpoint. Mixed-model analyses with total sleep time (TST, main predictor), week and fraction of time spent in physical activity (covariates), and subject (random effect), were performed. Among the community cohort, higher perceived stress, stressful events and distress and lower resilience were associated with shorter sleep, worse sleep quality, and gr...
Source: American Heart Journal - Category: Cardiology Source Type: research