Estimation of Chronic post-surgical pain after thoracic surgery: case closed?

I read with great interest the article of Gjeilo and colleagues in a recent issue of the journal (1). The authors completed a prospective study on 264 patients undergoing surgery for primary lung cancer and concluded that pain was highly prevalent after surgery, and subgroups could be identified based on different pain trajectories. The authors should be commended for performing a well-designed study in an important topic (e.g. pain) in patients undergoing surgery (2, 3). The need to identify the highest risk patients so specific preventive analgesic strategies can be tailored to patients who will benefit the most is a very pertinent topic in perioperative medicine (4, 5).
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research

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I read with great interest the article of Gjeilo et  al.1 in a recent issue of the journal. The authors completed a prospective study on 264 patients undergoing surgery for primary lung cancer and concluded that pain was highly prevalent after surgery, and subgroups could be identified based on different pain trajectories. The authors should be com mended for performing a well-designed study in an important topic (e.g., pain) in patients undergoing surgery.2,3 The need to identify the highest risk patients so specific preventive analgesic strategies can be tailored to patients who will benefit the most is a ...
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Tags: Letter Source Type: research
Yafei Tan1,2, Omer Van den Bergh2, Jiang Qiu1* and Andreas von Leupoldt2* 1Faculty of Psychology, Southwest University, Chongqing, China 2Health Psychology, KU Leuven, Leuven, Belgium Dyspnea is a prevalent interoceptive sensation and the aversive cardinal symptom in many cardiorespiratory diseases as well as in mental disorders. Especially the unpredictability of the occurrence of dyspnea episodes has been suggested to be highly anxiety provoking for affected patients. Moreover, previous studies demonstrated that unpredictable exteroceptive stimuli increased self-reports and electrophysiological responses of an...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In this study, we evaluated the effect of auranofin on the radiosensitivity of intestinal epithelial cells. The treatment with a combination of 1 μM auranofin and 5 Gy ionizing radiation showed clear additive effects on caspase 3 cleavage and apoptotic DNA fragmentation in IEC-6 cells, and auranofin administration significantly aggravated the radiation-induced intestinal injury in mice. Auranofin treatment also resulted in the activation of the unfolded protein response and in the inhibition of thioredoxin reductase, which is a key component of the cellular antioxidant system. Pre-treatment with N-acetyl cysteine, a wel...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 15 April 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Diederik De Cock, Kimme HyrichAbstractRheumatoid arthritis (RA) is a chronic inflammatory condition that can result in pain and functional disability. It is also associated with an increased occurrence of comorbidities, including an increased risk of certain cancers such as lung cancer and lymphoma. The aetiopathogenesis of this increased cancer risk is likely multifactorial and includes shared risk factors as well as chronic inflammation. There is also a concern that the treatment for RA itself may increase ...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
This study not only provides biological evidence to support the use of duloxetine as the first standard CIPN drug but will also lead to potential new targets for CIPN drug development. Introduction A major dose-limiting complication of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN). The greatest contributors to CIPN are taxanes (e.g., paclitaxel) and platinum-based (e.g., oxaliplatin) treatments (Krukowski et al., 2015). Paclitaxel (PTX) can effectively treat several of the most common cancers including breast cancer, lung cancer, and ovarian cancer (Ewertz et al., 2015; Cetinkaya-Fisgin et al., ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Among three large populations of older cancer survivors, chronic opioid use varied by cancer. However, by 6 years after diagnosis, survivors were no longer more likely to be chronic users than controls. Strategies for appropriate pain management during and after cancer treatment should take into account the risks associated with chronic high-dose opioid use. PMID: 30817249 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
At the end of life, chronic obstructive pulmonary disease (COPD) and lung cancer (LC) patients exhibit similar symptoms; however, a large-scale study comparing end-of-life health care utilization between these two groups has not been conducted in East Asia.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
This study aimed to determine the different delays in the management of lung cancers through a retrospective descriptive and analytical study on 131 hospitalized cases in service between April 2014 and January 2017. Management delays were estimated from the date of the first symptom described by the patient (D1s), the first contact with health care provider (1Cs), then hospitalization (DH) and finally to the histological confirmation of the diagnosis (C Hist) before the start of treatment (D ttt).Among the patients included in our work, 90.8% were men, 87.8% were chronic smokers. The mean age was 61 years; chest pain was t...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusions: free surgical margins are the main oncological prognostic factor in these patients. In patients who underwent resection of two or more ribs in a critical area, reconstruction of the bony thorax can significantly reduce the post-operative respiratory complication rate. PMID: 30026972 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Chronic obstructive pulmonary disease (COPD) patients often have several comorbidities, such as cardiovascular diseases (CVDs) or lung cancer (LC), which might influence resource use in the final months of life. However, no previous studies documented end-of-life resource use in COPD patients at a population level, thereby differentiating whether COPD patients die of their COPD, CVD, or LC.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Tags: Original Article Source Type: research
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