Fibulin-7 C-terminal fragment and its active synthetic peptide suppress choroidal and retinal neovascularization

Publication date: Available online 1 February 2020Source: Microvascular ResearchAuthor(s): Tomoko Ikeuchi, Yogita Kanan, Da Long, Susana de Vega, Kentaro Hozumi, Motoyoshi Nomizu, Peter A. Campochiaro, Yoshihiko YamadaAbstractWet age-related macular degeneration (AMD) and diabetic retinopathy are the leading causes of blindness through increased angiogenesis. Although VEGF-neutralizing proteins provide benefit, inconsistent responses indicate a need for new therapies. We previously identified the Fibulin-7 C-terminal fragment (Fbln7-C) as an angiogenesis inhibitor in vitro. Here we show that Fbln7-C inhibits neovascularization in vivo, in both a model of wet AMD involving choroidal neovascularization (CNV) and diabetic retinopathy involving oxygen-induced ischemic retinopathy. Furthermore, a short peptide sequence from Fbln7-C is responsible for the anti-angiogenic properties of Fbln7-C. Our work suggests Fbln7-C as a therapeutic candidate for wet AMD and ischemic retinopathy.
Source: Microvascular Research - Category: Biochemistry Source Type: research

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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
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Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
More News: Age-Related Macular Degeneration (AMD) | Biochemistry | Blindness | Diabetes | Endocrinology | Opthalmology | Vitamin A