Activity of delafloxacin versus that of levofloxacin against anaerobic and microaerophilic isolates.

Activity of delafloxacin versus that of levofloxacin against anaerobic and microaerophilic isolates. Anaerobe. 2020 Jan 24;:102150 Authors: Boyanova L, Yordanov D, Ouzounova-Raykova V, Markovska R, Marteva-Proevska Y, Mitov I Abstract The aim of the study was to comparatively assess delafloxacin and levofloxacin activities against 96 anaerobic and some microaerophilic isolates. Delafloxacin minimal inhibitory concentrations (MICs) were strikingly lower than those of levofloxacin. Delafloxacin MIC90 against clostridia, other Gram-positive rods, anaerobic/microaerophilic cocci and Gram-negative rods were 0.75, 0.032, 0.38 and 0.5 μg/mL, respectively. The highest (≥4 μg/mL) MICs of the newer fluoroquinolone were found in only 4.2% of isolates versus 46.9% by levofloxacin. The present results and the potency in acidic conditions showed delafloxacin advantages over levofloxacin in terms of usefulness for treatment of mixed anaerobic-aerobic infections and activity against Clostridioides (Clostridium) difficile. PMID: 31987991 [PubMed - as supplied by publisher]
Source: Anaerobe - Category: Microbiology Authors: Tags: Anaerobe Source Type: research