The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

ConclusionsAltogether, our results demonstrate that PRDM12 plays an essential role in the early establishment of hypothalamic melanocortin neuron identity and the maintenance of high expression levels of Pomc. Its absence in adult mice significantly impairs Pomc expression and leads to increased food intake, adiposity, and obesity.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research