Marital Status and Long-Term Outcomes in Mild Heart Failure Patients with an Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy with Defibrillator

Married patients have been shown to have a lower risk for adverse cardiovascular outcomes. However, the risk of heart failure (HF) or death in married versus unmarried patients with left ventricular (LV) dysfunction and an implantable cardioverter defibrillator (ICD), and the effect of cardiac resynchronization therapy with defibrillator (CRT-D) are unknown. In MADIT-CRT, among patients with LBBB, we evaluated long-term clinical outcomes of all-cause mortality or HF events in married (including common law status) compared to unmarried (single/divorced/widowed) patients with CRT-D vs.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research

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Impulse Dynamics, based in Mt. Laurel, New Jersey, has developed the Optimizer system, a device designed to improve myocardial contractility in patients with heart failure. The system is intended to improve the quality of life of heart failure patien...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiac Surgery Cardiology Exclusive Radiology Rehab Source Type: blogs
Condition:   Compare Two Programming Modalities for CRT Devices in Heart Failure Patients With an Indication for Cardiac Resynchronization Therapy Interventions:   Device: conventional CRT;   Device: MPP CRT Sponsor:   CMC Ambroise Paré Withdrawn
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Cardiac resynchronization therapy (CRT) has been associated to left ventricle (LV) remodelling, reduction of functional mitral regurgitation (FMR) and clinical improvement in patients with heart failure and reduced ejection fraction (HFrEF). The prevalence of significant FMR in patients with LV dyssynchrony that are candidate to CRT is up to 40%. Current approach in patients with FMR undergoing CRT consists of re-evaluation of the amount of FMR following a waiting period of at least 3  months after the implant.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Conclusions: CRT-D has higher greater cost-effectiveness across more subgroups in the indicated patient populations against as compared to OPT, ICD and CRT-P, from a US payer perspective. PMID: 32207659 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Condition:   Heart Failure Interventions:   Procedure: Temporary pacing Study;   Radiation: Thoracic CT;   Diagnostic Test: Acute hemodynamic study;   Diagnostic Test: Non-invasive body surface mapping;   Diagnostic Test: Invasive catheter-based mapping Sponsors:   Guy's and St Thomas' NHS Foundation Trust;   King's College London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsTherapy with CRT-D compared to CRT-P resulted in an additional gain of QALYs, but was more expensive. In addition, the ICER was subject to uncertainty, especially due to the uncertainty in the survival benefit. A randomised controlled trial and subgroup analyses would be desirable to further inform decision making.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
Abstract BACKGROUND: The impact of left ventricular reverse remodeling (LVRR) on the prognosis of Chagas cardiomyopathy is unknown. The aim of this study was to determine whether the presence of LVRR can predict mortality in these patients. METHODS: From January 2000 to December 2010, the medical charts of 159 patients were reviewed. LVRR was defined as an increase of left ventricular ejection fraction (LVEF) and a decrease of left ventricular end-diastolic diameter (LVDD) by two-dimensional echocardiography. No patient underwent cardiac resynchronization therapy or required mechanical ventricular assistance....
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
AbstractBackgroundCardiac resynchronization therapy(CRT) is an important and effective therapy for end ‐stage heart failure. Non‐response to CRT is one of the main obstacles to its application in clinical practice. Herein, we investigated the utilization of the optimization technique using NICOM based Mobil‐O‐Graph device which measures several circulation parameters non‐invasively.MethodsSeventy ‐five CRT non‐responder heart failure patients with an implanted CRT device were included. Patients were randomized equally to 3 groups: NICOM, echocardiographic and empirical optimization groups. After 3‐months of...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: DEVICES Source Type: research
AbstractBackgroundPermanent right ventricular pacing (RVP) results in cardiac dyssynchrony that may lead to heart failure and may be an indication for the use of cardiac resynchronization therapy (CRT). The study aimed to evaluate predictors of outcomes in patients with pacing ‐induced cardiomyopathy (PICM) if upgraded to CRT.Methods115 patients, 75.0 years old (IQR 67.0 –80.0), were upgraded to CRT due to the decline in left ventricle ejection fraction (LVEF) caused by the long‐term RVP. A retrospective analysis was performed using data from hospital and outpatient clinic records and survival data from the natio...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: DEVICES Source Type: research
Exercise oscillatory ventilation (EOV) is characterized by ventilatory control system instability with typical waxing and waning of tidal volume without interposed apnea during exercise.1 EOV has been observed in up to 50% of heart failure (HF) patients with similar frequency for those with either reduced2 or preserved3 left ventricular ejection fraction (LVEF). EOV has also been associated with increased mortality risk in HF patients with either reduced4 or preserved LVEF.3
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
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