Caffeine but not acetaminophen increases 4-km cycling time-trial performance

Publication date: Available online 25 January 2020Source: PharmaNutritionAuthor(s): F. Tomazini, A.C. Santos-Mariano, V.A. Andrade-Souza, V.C. Sebben, C.A. De Maria, D.B. Coelho, R. Bertuzzi, M.D. Silva-Cavalcante, A.E. Lima-SilvaAbstractAcetaminophen has been combined with caffeine for therapeutic purpose, but the effect of co-ingestion of acetaminophen and caffeine on exercise performance has not been investigated. To determine the effect of isolated and combined ingestion of caffeine and acetaminophen on performance during a 4-km cycling time-trial (4 T T). Eleven men, completed a 4 T T one hour after the ingestion of cellulose (PLA), acetaminophen (20 mg kg-1 body mass, ACT), caffeine (5 mg kg-1 body mass, CAF) or combined acetaminophen and caffeine (20 and 5 mg kg-1 body mass, respectively, ACTCAF). The perception of pain, rating of perceived exertion, electromyography, oxygen uptake were recorded. Plasma lactate concentration was measured before and immediately after the trial. The time and mean power during the 4 T T was significantly improved (P <  0.05) in CAF (407.9 ± 24.5 s, 241.4 ± 16.1 W) compared to PLA (416.1 ± 34.1 s, 234.1 ± 19.2 W) and ACT (416.2 ± 26.6 s, 235.8 ± 19.7 W). However, there was no difference between ACTCAF (411.6 ± 27.7 s, 238.7 ± 18.7 W) and the other conditions (P >  0.05). All other measures were similar under the conditions (P >  0.05). Caffeine but not acetaminophen increases power output ult...
Source: PharmaNutrition - Category: Nutrition Source Type: research