Caffeine but not acetaminophen increases 4-km cycling time-trial performance

Publication date: Available online 25 January 2020Source: PharmaNutritionAuthor(s): F. Tomazini, A.C. Santos-Mariano, V.A. Andrade-Souza, V.C. Sebben, C.A. De Maria, D.B. Coelho, R. Bertuzzi, M.D. Silva-Cavalcante, A.E. Lima-SilvaAbstractAcetaminophen has been combined with caffeine for therapeutic purpose, but the effect of co-ingestion of acetaminophen and caffeine on exercise performance has not been investigated. To determine the effect of isolated and combined ingestion of caffeine and acetaminophen on performance during a 4-km cycling time-trial (4 T T). Eleven men, completed a 4 T T one hour after the ingestion of cellulose (PLA), acetaminophen (20 mg kg-1 body mass, ACT), caffeine (5 mg kg-1 body mass, CAF) or combined acetaminophen and caffeine (20 and 5 mg kg-1 body mass, respectively, ACTCAF). The perception of pain, rating of perceived exertion, electromyography, oxygen uptake were recorded. Plasma lactate concentration was measured before and immediately after the trial. The time and mean power during the 4 T T was significantly improved (P   0.05). All other measures were similar under the conditions (P >  0.05). Caffeine but not acetaminophen increases power output ultimately increasing performance during a 4TT.Graphical abstract
Source: PharmaNutrition - Category: Nutrition Source Type: research

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We report a case of a young male with no prior genitourinary history who presents to an emergency department with sudden onset gross hematuria, clot retention, and right-sided flank pain. On evaluation, he was found to have a renal artery aneurysm bleeding into his collecting system and underwent renal artery embolization and rapid resolution of his hematuria. Renal vascular pathology should be considered in the differential diagnosis and timely diagnosis of this condition is imperative as surgical interventions have proven to be life-saving. PMID: 32065873 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
CONCLUSIONS: BTX-A treatment using either a trigone-sparing or trigone-including injection template resulted in significant, but not location-dependent, improvement in IC/BPS symptom scores at 30 and 90 day points post-procedure with no significant difference in post-treatment complication profiles. PMID: 32065870 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
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Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
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Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Publication date: Available online 18 February 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Alexandre Lannou, Cédric Carrié, Sébastien Rubin, Hugues De Courson, Matthieu Biais
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 18 February 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Mathieu Tourangeau, Issam Tanoubi, Roger Perron, Marie-Ève Bélanger, Komi Sodoké, Pierre Drolet, Arnaud Robitaille, Mihai Georgescu
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
In this study, 91 adolescents (10-24 years; 78 females) including 30 chronic pain patients with high pain-related distress, 29 chronic pain patients with low pain-related distress, and 32 healthy peers without chronic pain completed a developmentally appropriate T–S learning paradigm. We measured self-reported fear, psychophysiology (skin conductance response), and functional magnetic resonance imaging responses (N = 72 after functional magnetic resonance imaging exclusions). After controlling for age and anxiety symptoms, patients with high pain-related distress showed altered self-reported fear and frontolimbic act...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
This study provided no evidence for the hypothesis that chronic pain is associated with accelerated brain aging (Welch t test, P = 0.74, Cohen's d = 0.061). A Bayesian independent-samples t test indicated moderate evidence in favor of the null hypothesis (BF01 = 4.875, ie, group means were equal). Our results provide indirect support for recent models of pain-related changes of brain structure, brain function, and cognitive functions. These models postulate network-specific maladaptive plasticity, rather than widespread or global neural degeneration.
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pain (pain present most or every day, prior 3 months) was 40.5%: 15.4% with mild chronic pain (lower pain intensity and interference); 10.1% bothersome chronic pain (moderate to severe pain intensity with lower interference with life activities); and 15.0% high-impact chronic pain (sustained pain-related activit...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
No abstract available
Source: Pain - Category: Anesthesiology Tags: Commentary Source Type: research
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