Effect of Lactobacillus Plantarum Containing Probiotics on Blood Pressure: A systematic review and meta-analysis

Publication date: Available online 24 January 2020Source: Pharmacological ResearchAuthor(s): Anne-Mary Lewis-Mikhael, Amirhossein Davoodvandi, Sadegh JafarnejadAbstractPrevious studies have recommended that probiotics may have blood pressure (BP)-lowering effects. However, they examined all probiotic strains (multi/single probiotics) simultaneously. In respect to strain specificity properties of probiotic, the aim of the present study was to systematically investigate the role of Lactobacillus plantarum as an anti-hypertensive agent by performing a meta-analysis of randomized controlled trials. PubMed, Scopus, Cochrane Library and Google Scholar were used from inception until October 2018 to identify eligible trials. We used random-effects model as the preferable method to assess the combined treatment effect. We further conducted sensitivity analysis and stratified analysis. Seven studies with 653 participants were included in the meta-analysis. The pooled weighted mean difference (WMD) with the random effects model showed a significant effects of Lactobacillus plantarum supplementation on improvement of SBP with no statistically significant heterogeneity (WMD: -1.58 mmHg, 95% CI: -3.05 to 0.11) (heterogeneity P = 0.14; I² = 36%). The overall effect in the DBP showed significant pooled estimates (WMD: -0.92 mmHg, 95% CI: -1.49 to -0.35) with a complete homogeneity between the studies (heterogeneity P = 0.46; I² = 0%). The findings of the present meta-an...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research