Neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels decrease in male mouse MPG following cavernous nerve injury or explant culture.

Neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels decrease in male mouse MPG following cavernous nerve injury or explant culture. Am J Physiol Renal Physiol. 2013 Sep 18; Authors: Girard BM, Merriam LA, Tompkins JD, Vizzard MA, Parsons RL Abstract Quantitative real time-PCR was used to test whether cavernous nerve injury leads to a decrease in major pelvic ganglia (MPG) neuronal nicotinic acetylcholine receptor (nAChR) subunit and postsynaptic density-93 (PSD-93) transcript levels. Subunits α3, β4 and α7, commonly expressed in MPG, were selected for analysis. After 72 hours in explant culture, MPG transcript levels for α3, β4, α7, and PSD-93 were depressed significantly. Three days following cavernous nerve axotomy or crush in vivo, transcript levels for α3, β4 and PSD-93, but not for α7, were significantly depressed. Three days after dissecting the cavernous nerve free of underlying tissue and applying a 5 mm lateral stretch (manipulation), the transcript levels for α3 and PSD-93 also were decreased significantly. Seven days following all 3 surgical procedures, α3 transcript levels remained depressed, but PSD-93 transcript levels were still decreased only following axotomy or nerve crush. At 30 days post surgery, transcript levels for the nAChR subunits and PSD-93 had recovered. Acetylcholine-induced currents were significantly smaller in MPG neurons dissociated from ...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Authors: Santos VA, Hoirisch-Clapauch S, Nardi AE, Freire RC Abstract Background: Acute administration of caffeine produces panic attacks in most Panic Disorder (PD) patients, but little is known about chronic caffeine use in these patients. Objective: To assess caffeine use in patients with PD and to ascertain if caffeine consumption is associated with sociodemographic or clinical features. Methods: 65 adults with PD and 66 healthy controls were included in the current study. Their caffeine intake within the previous week was quantified with a questionnaire and compared. Harmful caffeine use was defined as...
Source: Clinical Practice and Epidemiology in Mental Health - Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research
Conclusion: Individuals in homologous MAR are a more distressed subgroup which requires a tailored supportive psychological intervention specifically on sexual and social concerns. PMID: 31819758 [PubMed]
Source: Clinical Practice and Epidemiology in Mental Health - Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research
Conclusion: These findings demand a change in cultural attitudes toward domestic disputes and mental health concerns, and a redefining of the community's responsibility in IPHS. The warning signs associated with IPHS should be part of existing violence and suicide prevention programs. PMID: 31819747 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
ConclusionsBoth low and risky levels of alcohol use in early adolescence are associated with internaliisng symptoms. The findings have implications for the timing of school-based prevention programs, and suggest future preventive efforts should adopt a combined approach to reducing alcohol use and mental health disorders in tandem.
Source: Mental Health and Prevention - Category: Psychiatry Source Type: research
Conclusion: Our results demonstrated that a significant percentage of patients affected by both mood disorders and schizophrenia shows relevant social dysfunction. Social dysfunction is related, but not completely explained by psychopathological severity. In several patients, it tends to persist also during remission state. Socio-demographic and lifestyle factors were also found to play a role and should therefore be taken into consideration in further studies investigating social dysfunction.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Psychiatric ResearchAuthor(s): Madhukar H. Trivedi, Cherise Chin Fatt, Manish K. Jha, Crystal M. Cooper, Joseph M. Trombello, Brittany L. Mason, Jennifer Hughes, Bharathi S. Gadad, Andrew H. Czysz, Russell T. Toll, Anne K. Fuller, Sangita Sethuram, Taryn L. Mayes, Abu Minhajuddin, Thomas Carmody, Tracy L. GreerAbstract:Depression has a chronic and recurrent course often with early onset and is the leading cause of disability worldwide. In contrast to diagnoses for other conditions which rely on precise medical tests, the diagnosis of depression still foc...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 10 December 2019Source: NeuroImageAuthor(s): Daniel Smieja, Benjamin T. Dunkley, Blake C. Papsin, Vijayalakshmi Easwar, Hiroshi Yamazaki, Michael Deighton, Karen A. GordonAbstractDespite early bilateral cochlear implantation, children with congenital deafness do not develop accurate spatial hearing; we thus asked whether auditory brain networks are disrupted in these children. EEG responses were evoked unilaterally and bilaterally in 13 children with normal hearing and 16 children receiving bilateral cochlear implants simultaneously. Active cortical areas were estimated by the Time Restri...
Source: NeuroImage - Category: Neuroscience Source Type: research
The next test for psilocybin will be to treat depression resistant to existing drugs
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
Youth who are taking antidepressants in the class of serotonin reuptake inhibitors (SSRIs) for anxiety or obsessive compulsive disorder (OCD) are more likely to experience side effects that cause them to discontinue the medication than those taking serotonin-norepinephrine inhibitors (SNRIs), according to a report in theJournal of the American Academy of Child and Adolescent Psychiatry.SSRIs also appear to be more commonly associated with “activation syndrome”—a cluster of symptoms including restlessness, anxiety, and agitation.Both classes of antidepressants are commonly prescribed for young people with ...
Source: Psychiatr News - Category: Psychiatry Tags: Journal of the American Academy of Adolescent Psychiatry medications for youth with anxiety and OCD selective serotonin reuptake inhibitor side effects SNRIs treatment discontinuation Source Type: research
Authors: Wietersheim JV, Knoblauch JD, Rottler E, Weiß H, Hartmann A, Rochlitz P, Völker A, Scheidt CE, Beutel ME, Eckhardt-Henn A, Zeeck A Abstract Several therapeutic treatments like individual psychotherapy, group therapy, creative therapies and talks with the nursing staff are components in an inpatient psychosomatic (psychotherapeutic) treatment or a psychosomatic day hospital treatment. In Germany, these therapies have to be documented by the administration with so called OPS-Codes. These codes are reported to the Institute for Reimbursement in Hospitals (InEK). With the data of the INDDEP-study it...
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
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