One-pot synthesis of copper-doped mesoporous bioglass towards multifunctional 3D nanofibrous scaffolds for bone regeneration

Publication date: 15 March 2020Source: Journal of Non-Crystalline Solids, Volume 532Author(s): Honglin Luo, Jian Xiao, Mengxia Peng, Quanchao Zhang, Zhiwei Yang, Hongjuan Si, Yizao WanAbstractA multifunctional bioactive material with osteogenic and antibacterial performance is of crucial importance for the repair of large bone defects. Herein, three-dimensional (3D) mesoporous bioactive glass (MBG) nanofibrous scaffolds doped with copper (Cu) were synthesized via a one-pot template-assisted sol-gel method followed by calcination. The morphology, structure, pore structure, in vitro bioactivity, cell biocompatibility, and antibacterial activity of the as-prepared 3D Cu-doped MBG nanofibrous scaffolds with varying amounts of doped Cu were characterized and compared. The results demonstrate that, besides large specific surface areas and a well-defined three-dimensional (3D) network structure, the as-prepared scaffolds exhibit good in vitro bioactivity and biocompatibility and excellent antibacterial activity against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. It is believed that the 3D Cu-doped MBG nanofibrous scaffolds show potential application in preventing infections.
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research