Human pSTAT3-Inhibited Itregs Prevent Gvhd, Maintain Anti-Leukemia Immunity, and Increase Their Potency after Metabolic Reprogramming

Immune suppressive donor regulatory T cells (Tregs) can be expanded to prevent or treat graft-versus-host disease (GVHD). In human induced Tregs (iTregs), we demonstrated that inhibiting STAT3 phosphorylation (pSTAT3) with S3I-201 increases demethylated Foxp3 and significantly improves their suppressive potency in vitro, mitigating phenotypically plastic iTreg de-differentiation.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Kelly Walton, Mario R. Fernandez, Elizabeth M. Sagatys, Jordan Reff, Jongphil Kim, Marie C. Lee, John V. Kiluk, Nicholas J. Lawrence, Harshani R. Lawrence, Joseph A. Pidala, Steven Z. Pavletic, Bruce R. Blazar, Said M. Sebti, John L Cleveland, Claudio Ana Tags: 238 Source Type: research