Virus-Specific T Cells (VSTs) Therapy for Progressive Multifocal Leukoencephalopathy (PML)- a Novel Therapy to Combat a Fatal Disease

PML is a rare infection with JC virus affecting mostly oligodendrocytes and the white matter of the central nervous system. It affects patients with profound cellular immunodeficiency such as uncontrolled HIV or those receiving immunosuppression for neoplastic and autoimmune diseases. Prognosis is poor as there is no effective therapy except for immune recovery which is not feasible in all cases. Herein, we describe using Quadrivalent (CMV,EBV, Adenovirus and BK) VSTs in a recipient of an unrelated donor hematopoietic cell transplant (HCT) with PML.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Michael S. Grimley, Galyna Clous, Alice Mims, Sumithira Vasu, Jon Mickle, Christina Liscynesky, Catherine M. Bollard, Michael D. Keller, Patrick J. Hanley, Jamie Wilhelm, Stella M. Davies, Adam S. Nelson, Zeinab El Boghdadly Tags: 520 Source Type: research