Long non-coding RNA expression identified by microarray analysis: Candidate biomarkers in human acral lentiginous melanoma.

Long non-coding RNA expression identified by microarray analysis: Candidate biomarkers in human acral lentiginous melanoma. Oncol Lett. 2020 Feb;19(2):1465-1477 Authors: Shi HZ, Xiong JS, Xu CC, Bu WB, Wang Y, Sun JF, Chen H Abstract Melanoma is a rare but fatal form of skin cancer and acral lentiginous melanoma (ALM) is one of its most common types. Long non-coding RNA (lncRNA) has emerged as a crucial molecule in the development and progression of human cancers, and several studies have revealed that lncRNAs may be associated with the pathogenesis, progression and metastasis of melanoma. To demonstrate the association between ALM and lncRNAs, microarray analysis was performed in tumor and adjacent non-tumor tissues. A total of 4,488 lncRNAs and 3,913 mRNAs were identified to be differentially expressed in these samples. Among them, 2,211 and 2,277 lncRNAs were upregulated and downregulated in the ALM samples compared with adjacent tissues, respectively. In addition, 1,191 and 2,722 mRNAs were upregulated and downregulated, respectively. Additionally, five randomly selected lncRNAs (fold-change>2; P
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

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Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Christopher E. Rudd, Kittiphat Chanthong, Alison TaylorSummaryImmune checkpoint blockade using antibodies against negative co-receptors such as cytolytic T cell antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) has seen much success treating cancer. However, most patients are still not cured, underscoring the need for improved treatments and the possible development of small molecule inhibitors (SMIs) for improved immunotherapy. We previously showed that glycogen synthase kinase (GSK)-3α/β is a central regulator of PD-1...
Source: Cell Reports - Category: Cytology Source Type: research
anazi Garrett Melanoma is the most lethal form of skin cancer. Melanoma is usually curable with surgery if detected early, however, treatment options for patients with metastatic melanoma are limited and the five-year survival rate for metastatic melanoma had been 15–20% before the advent of immunotherapy. Treatment with immune checkpoint inhibitors has increased long-term survival outcomes in patients with advanced melanoma to as high as 50% although individual response can vary greatly. A mutation within the MAPK pathway leads to uncontrollable growth and ultimately develops into cancer. The most common ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
This study aimed at investigating the value of applying positron emission tomography (PET) to early predict the effect of immune checkpoint inhibitors (ICIs) in malignant tumors.MethodsElectronic databases MEDLINE/PubMed, EMBASE, and Cochrane Library were searched to identify relevant trials. The primary endpoints were progression-free survival (PFS) and overall survival (OS). The results were analyzed utilizing SPSS 19.0 statistical software. Subgroup analyses were implemented based on primary  tumors, study designs, continents, type of ICIs, evaluation index of PET, and evaluated PET timing.ResultsFifteen studi...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
(CNN) — States with the highest rates of melanoma cases linked to ultraviolet radiation are spread across the United States on the East and West coasts, in Hawaii and in landlocked states, according to a study published Monday in the International Journal of Cancer. Melanoma is one of the most rapidly increasing cancers in the United States, jumping 2% per year between 2005 and 2015 in both men and women, the study found, with an estimated 151,000 cases a year by 2030 up from just over 96,000 in 2019, if current trends continue. It is also the deadliest type of all skin cancers and linked to UV radiation exposure in ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN New Hampshire News Skin Cancer Vermont News Source Type: news
Title: Melanoma Cases Rising in U.S.Category: Health NewsCreated: 2/18/2020 12:00:00 AMLast Editorial Review: 2/18/2020 12:00:00 AM
Source: MedicineNet Cancer General - Category: Cancer & Oncology Source Type: news
States with the highest rates of melanoma cases linked to ultraviolet radiation are spread across the United States on the East and West coasts, in Hawaii and in landlocked states, according to a study published Monday in the International Journal of Cancer.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Rhophilin Rho GTPase binding protein 1 antisense RNA 1 (RHPN1-AS1) is a newly discovered oncogene in several diseases, such as breast cancer, non-small cell lung cancer and uveal melanoma. Nevertheless, its mo...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
This study aims to externally validate the Liverpool Uveal Melanoma Prognosticator Online V3 (LUMPO3) to determine its reliability in predicting survival after treatment for choroidal melanoma when utilizing external data from other ocular oncology centers. Anonymized data of 1836 UM patients from seven international ocular oncology centers were analyzed with LUMPO3 to predict the 10-year survival for each patient in each external dataset. The analysts were masked to the patient outcomes. Model predictions were sent to an independent statistician to evaluate LUMPO3’s performance using discrimination and calibrati...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
y Levade Nathalie Andrieu-Abadie The roles of ceramide and its catabolites, i.e., sphingosine and sphingosine 1-phosphate, in the development of malignancies and the response to anticancer regimens have been extensively described. Moreover, an abundant literature points to the effects of glucosylceramide synthase, the mammalian enzyme that converts ceramide to β-glucosylceramide, in protecting tumor cells from chemotherapy. Much less is known about the contribution of β-glucosylceramide and its breakdown products in cancer progression. In this chapter, we first review published and personal clinical...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
In their article, Baldini et al. evaluated the association between immune-related adverse events (irAEs) and clinical benefit among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab in the Italian NSCLC expanded access program [1]. Accumulating evidence suggest that there is a correlation between irAEs incidence and therapeutic outcomes of immunotherapy. This has been widely demonstrated in several solid tumors, mostly in patients with melanoma [2] and NSCLC [3]. However, most retrospective reports in NSCLC mainly include patients of Asian ethnicity [4], and differences in treatment tolerability and o...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
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