Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan

Condition:   Diabetes Mellitus, Type 2 Interventions:   Drug: Metformin and Glimepiride (Low Dosage);   Drug: Metformin and Vildagliptin (Low Dosage);   Drug: Metformin and Insulin Glargine U100 (Low Dosage);   Drug: Metformin, Insulin Glargine U100, and Human Regular Insulin (Low Dosage);   Drug: Metformin and Glimepiride (Regular  Dosage);   Drug: Metformin and Vildagliptin (Regular Dosage);   Drug: Metformin and Insulin Glargine U100 (Regular Dosage);   Drug: Metformin, Insulin Glargine U100, and Human Regular Insulin (Regular Dosage) Sponsor:   University of Jordan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 16 February 2020Source: Canadian Journal of DiabetesAuthor(s): Tomoyuki Kawada
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
This article aims to classify the severity grading assessments for both insulin resistance (IR) syndrome and status of pancreatic beta (β) islet cells’ function using the homeostasis model assessment method (that is; homeostasis model assessment-insulin resistance [HOMA-IR] and homeostasis model assessment-pancreatic beta (β) islet cells’ function [HOMA-B] indices) with the focus of disseminating this information rapidly for clinical use by physicians in their patients with dysfunctional regulation of glucose metabolism. It will also assist clinicians to prevent and screen for these individuals who ar...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
TYPE 2 diabetes is a chronic condition that requires careful monitoring to stave off the risks posed by rising blood sugar levels. Sugar can wreak havoc on blood sugar management, but a natural sugar substitute has been shown to have a positive impact on blood sugar levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 15 February 2020Source: Life SciencesAuthor(s): Adham M. Maher, Samar R. Saleh, Nihal M. Elguindy, Hagar M. Hashem, Galila A. YacoutAbstractAim of the workNeuroinflammation can arise from metabolic disturbances accompanying type 2 diabetes mellitus (T2DM) with an implication of indoleamine 2,3-dioxygenase 1 (IDO1). The antioxidant and anti-inflammatory potentials of melatonin (Mel) can amend diabetic complications. Here, we examined the effect of exogenous melatonin on neuroinflammation in high fat diet (HFD)-induced T2DM rats.Main methodsTwenty-one adult male Sprague-dawley rats were div...
Source: Life Sciences - Category: Biology Source Type: research
Type 2 diabetes mellitus (T2DM) is a considerable risk factor of cardiovascular disease, heart failure, chronic kidney disease, and mortality [1 –4]. Diabetes caused 4 million deaths in 2017, with more than 0.84 million in China [5]. The prevalence of T2DM is increasing in many countries with the speeding up of urbanization and change in lifestyle. The International Diabetes Federation estimated that approximately 425 million adults (20– 79 years) were living with diabetes in 2017, 79% were from low- and middle-income countries, and this number would rise to 629 million by 2045 [5].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Conclusions: A unique pattern of prescription was observed amongst Japanese patients with T2DM, and DPP4i, rather than metformin, was predominantly used as the first-line treatment. SGLT2i was infrequently prescribed. Metformin was prescribed at a daily dose of ≤500 mg in many patients. Greater efforts are needed to assess the comparative effectiveness of these treatment strategies. PMID: 32050809 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Grgurevic I, Podrug K, Mikolasevic I, Kukla M, Madir A, Tsochatzis EA Abstract Nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide, associated with epidemics of overweight and resulting metabolic syndrome (MetS). Around 20-30% of patients with NAFLD develop progressive liver fibrosis, which is the most important predictor of liver-related and overall morbidity and mortality. In contrast to classical understanding, no significant association has been demonstrated between the inflammatory component of NAFLD, i.e., nonalcoholic steatohepatitis (NASH), and the advers...
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
Gallbladder cancer is the most common biliary tract cancer with poor prognosis and wide variation in incidence rates worldwide, being very high in some countries in Latin America and Asia. Treatment of type 2 diabetes with metformin causes a reduction in the incidence of cancer. Till date, there are no reports on the anti-tumor effects of metformin in gall bladder cancer. Therefore, this study evaluated the effects of metformin on the proliferation of human gallbladder adenocarcinoma cells in vitro and in vivo, as well as explored the microRNAs associated with the anti-tumor effects of metformin. Metformin inhibited the pr...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Authors: Maejima T, Kumagai K, Yabe K, Yasuno K, Ishikawa K, Okado K, Sasaki N, Kai K, Mori K Abstract A 40-week-old male spontaneous diabetic Torii rat, an animal model of type 2 diabetes mellitus, was found to have marked urinary calculi with hematuria in the urinary bladder on necropsy. Histological findings in the urinary bladder included a papillary growth pattern with a fibrovascular stroma without atypia. Fine granular materials in the bladder lumen were positive for Von Kossa staining but negative for periodic acid-Schiff or Gram staining, indicating no apparent bacterial infection in the urinary bladder. S...
Source: Journal of Toxicologic Pathology - Category: Toxicology Tags: J Toxicol Pathol Source Type: research
Conclusion: Candidates for bariatric/metabolic surgery favored SG followed by AGB, GP, and RYGB, and their choices were compatible with current evidence-based clinical practice. PMID: 32051816 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
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