Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study

ConclusionFindings suggest that HVul might be at increased risk of developing anhedonic symptoms due to weaker encoding of reward value, higherdifficultytoengageingoal-orientedbehaviorsandincreasedsensitivitytonegativefeedback, particularly in stressful contexts. These findings open new avenues for a better understanding of the mechanisms underlying how the complex interaction between the systems of stress and reward responsiveness contribute to the vulnerability to MDD, and how cognitive resources might modulate this interaction.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research