The New Surveillance, Epidemiology, and End Results Prostate with Watchful Waiting Database: Opportunities and Limitations
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Chang Wook Jeong, Samuel L. Washington, Annika Herlemann, Scarlett L. Gomez, Peter R. Carroll, Matthew R. CooperbergAbstractBackgroundActive surveillance (AS)/watchful waiting (WW) strategy for localized prostate cancer (PCa) is increasingly and broadly endorsed as a preferred option for initial treatment of men with very low- and low-risk PCa, but outcomes can be difficult to analyze in traditional, population-based registries. The recently released Surveillance, Epidemiology, and End Results (SEER) Prostate with WW dataset provides an opportunity to understand national patterns and trends in AS/WW, but the data source itself has not been well described.ObjectiveTo provide a comprehensive description of this dataset and investigate possible biases due to missing data.Design, setting, and participantsThe SEER is a population-based epidemiologic registry in the USA. Newly diagnosed PCa patient data were collected from 18 SEER registries between 2010 and 2015, with inclusion of a new treatment variable for AS/WW. We identified 316 724 patients in the entire cohort and 257 060 men with clinically localized PCa (T1-2N0M0).InterventionVarious primary treatments for PCa.Outcome measurements and statistical analysisThe degree of missing data for each variable was measured. In order to investigate possible bias due to missing data for cancer characterization, we compared two versions of the data: one...
Conditions: Prostate Adenocarcinoma; Lower Urinary Tract Symptoms Intervention: Combination Product: Bicalutamide implant Sponsor: Alessa Therapeutics Inc. Not yet recruiting
CONCLUSION: Patients who were exposed to asbestos should possibly be encouraged to complete more frequent prostate cancer screening. PMID: 32097115 [PubMed - as supplied by publisher]
Publication date: Available online 25 February 2020Source: European UrologyAuthor(s): Francesco Montorsi, Giorgio Gandaglia, Nicola Fossati, Andrea Salonia, Alberto Briganti
Objectives: We sought to evaluate sociodemographic disparities in insurance coverage among nonelderly adults with a common cancer after Affordable Care Act (ACA) implementation. Patients and Methods: In total, 109,182 patients aged 18 to 64 years diagnosed with a common cancer (lung, breast, or prostate cancer) were identified from 2010 to 2014. Multivariable logistic regressions analyzed associations between ACA implementation and uninsured rates on the basis of state approach to Medicaid expansion, stratified by race (black, white), and income (stratified at 138% Federal Poverty Line). Results: Uninsured rates de...
PMID: 32092344 [PubMed - as supplied by publisher]
This study quantified plan quality differences across the four cancer centers in XXX(blinded for review) for plans that followed the PROstate Fractionated Irradiation Trial (PROFIT) protocol.
Conclusions: RT, despite modern techniques, affects the sexual function of PCa patients in varying degrees. Reducing radiation doses to penile structures may play a role in preventing erectile dysfunction.
on Peehl Kurhanewicz Non-invasive assessment of the biological aggressiveness of prostate cancer (PCa) is needed for men with localized disease. Hyperpolarized (HP) 13C magnetic resonance (MR) spectroscopy is a powerful approach to image metabolism, specifically the conversion of HP [1-13C]pyruvate to [1-13C]lactate, catalyzed by lactate dehydrogenase (LDH). Significant increase in tumor lactate was measured in high-grade PCa relative to benign and low-grade cancer, suggesting that HP 13C MR could distinguish low-risk (Gleason score ≤3 + 4) from high-risk (Gleason score ≥4 + 3) PCa. To test this and...
ConclusionsNegative68Ga-PSMA PET/CT results were highly reliable in our study. Positive68Ga-PSMA PET/CT results, however, revealed less reliable results. Larger and ideally prospective trials are justified to clarify the potential role of PSMA PET/CT based primary staging.