RAB27A/Melanophilin blocker inhibits melanoma cell motility and invasion.

Melanoma is cancer caused by the neoplastic transformation of melanocytes. The last decade has witnessed a surge in treatment options for advanced melanoma patients, especially immunotherapeutic interventions; nonetheless, issues such as drug resistance, limited efficacy, and high-toxicity ensue (Luke et al., 2017). Understanding the mechanisms underpinning melanoma progression and invasion is, therefore, vital for the development of treatment strategies.

Source: Journal of Investigative Dermatology - January 20, 2020 Category: Dermatology Authors: Dajiang Guo, Rohit Jain, Jae Sung Hwang, Wolfgang Weninger, Kimberley A. Beaumont, Shweta Tikoo Tags: Letters to the Editor Source Type: research