The Role of Long Non-Coding RNAs in Atrial Fibrillation

Atrial Fibrillation (AF) is a common arrhythmia with serious clinical sequelae, but despite its significance little is known about the genetic origins. Recently, the untranscribed 98% of the human genome has been increasingly implicated in important processes like cardiac organogenesis, physiology, and pathophysiology. Specifically, long non-coding RNAs (lncRNA) have been shown to interact with the transcriptome in various ways that alter gene expression. Previously, multiple lncRNAs have been identified in disease processes such as heart failure, coronary artery disease, diabetes, and more.

Source: Heart Rhythm - January 20, 2020 Category: Cardiology Authors: Savalan Babapoor-Farrokhran, Deanna Gill, Roozbeh Tarighati Rasekhi Source Type: research