Combining antigen detection and serology for the diagnosis of selected infectious diseases

Publication date: Available online 20 January 2020Source: Methods in MicrobiologyAuthor(s): Maria M. Plummer, Charles S. PaviaAbstractImmunoassay detection of specific antigens and host-produced antibodies directed against such antigens constitute two of the most widely used and successful methods for diagnosing infectious diseases and many of the non-infectious autoimmune disorders. We will be reviewing some of the epidemiology, microbiology, and clinical aspects of selected organisms and discuss their diagnosis by describing some of the major antigen detection systems and serologic techniques available to health care providers. The pathogens to be discussed include Streptococcus pyogenes, Streptococcus pneumoniae, Legionella pneumophila, Helicobacter pylori, Coccidioides immitis, and Cryptococcus neoformans.
Source: Methods in Microbiology - Category: Microbiology Source Type: research

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Publication date: 22–28 February 2020Source: The Lancet, Volume 395, Issue 10224Author(s): Florian Desgranges, Alix T Coste, Diane Wernly, Justine Dufour, Onya Opota, Sylvain Meylan
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionsAnti-DFS70 autoantibodies might be considered a biomarker to differentiate patients with SLE from ANA-positive individuals without autoimmune diseases.Key Points:• In a Latin American cohort, the anti-DFS70 was higher in individuals without autoimmune diseases compared with that in patients with SLE.• The anti-DFS70 might have utility as a biomarker of exclusion in patients with non-specific clinical signs of AARDs.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This article is categorized under: Biological Mechanisms> Metabolism Translational, Genomic, and Systems Medicine> Translational Medicine Physiology> Mammalian Physiology in Health and Disease
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - Category: Biomedical Science Authors: Tags: ADVANCED REVIEW Source Type: research
The field of Alzheimer's disease research is in the midst of a slow-moving and consequential debate over the role of infection in the development of the condition. The fundamental question is this: in the absence of genetic variants that raise risk, why do only some people progress to full blown Alzheimer's disease? The presence - in only some people - of sufficient degrees of persistent infection is one possible answer to that question. Candidates include herpesviruses, oral bacteria such as P. gingivalis, lyme disease spirochetes, and others. Alzheimer's is a condition characterized by amyloid-β aggregation i...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
No abstract available
Source: Nursing - Category: Nursing Tags: Department: INFECTION PREVENTION Source Type: research
In conclusion, VEGF polymorphisms with lower activity were associated with the severity of HD, while VEGFR2 polymorphisms and the combinations of VEGF and VEGFR2 polymorphisms, which have stronger interactions, were associated with the intractability of GD. VEGF and VEGFR2 polymorphisms were associated with HD severity and GD intractability, respectively. PMID: 32074519 [PubMed - as supplied by publisher]
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
FRIDAY, Feb. 21, 2020 -- Taking their medications as prescribed significantly lowers lupus patients'risk of developing diabetes, a new study finds. Type 2 diabetes is a common complication of lupus, an autoimmune disease that can cause damaging...
Source: - Daily MedNews - Category: General Medicine Source Type: news
We’ve all been there. You awaken in the morning and one of your hands is completely numb. It feels dead, heavy, and simply won’t work. Perhaps there’s some tingling as well. Or, you arise from a long dinner or movie and one of your legs feels that way. Then over a few minutes — maybe you shook your hands, stamped your foot — everything goes back to normal. Until the next time. The first time this happened, it might have been worrisome. Now that you know it’s temporary and happens to everyone, it may not bother you. But did you ever wonder why in the world this happens? Read on! When the ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Healthy Aging Neurological conditions Source Type: blogs
[Radio Dabanga] Red Sea State / El Gezira -The deaths of large numbers of livestock and cases of fever among residents in Aryab in Sudan's Red Sea state, have raised concerns for the possible re-emergence of Rift Valley fever in the area. Mycetoma infections are plaguing El Gezira state.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Authors: Ingawale DK, Mandlik SK Abstract Inflammation is a physiological intrinsic host response to injury meant for removal of noxious stimuli and maintenance of homeostasis. It is a defensive body mechanism that involves immune cells, blood vessels and molecular mediators of inflammation. Glucocorticoids (GCs) are steroidal hormones responsible for regulation of homeostatic and metabolic functions of body. Synthetic GCs are the most useful anti-inflammatory drugs used for the treatment of chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), allergies, multiple sclerosis, te...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
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