SNAP25/syntaxin4/VAMP2/Munc18-1 complexes in spinal dorsal horn contributed to inflammatory pain

Publication date: Available online 19 January 2020Source: NeuroscienceAuthor(s): Xing-Lian Duan, Zhen Guo, Yong-Tao He, Yin-Xia Li, Yan-Ni Liu, Hu-Hu Bai, Hu-Ling Li, Xiao-Dong Hu, Zhan-Wei SuoAbstractSoluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) have been implicated in the trafficking of postsynaptic glutamate receptors, including N-methyl-D-aspartate (NMDA)-subtype glutamate receptors (NMDARs) that are critical for nociceptive plasticity and behavioral sensitization. However, the components of SNAREs complex involved in spinal nociceptive processing remain largely unknown. Here we found that SNAP25, syntaxin4, VAMP2 and Munc18-1 were localized at postsynaptic sites and formed the complex in the superficial lamina of spinal cord dorsal horn of rats. The complex formation between these SNAREs components were accelerated after intraplantar injection of complete Freund's adjuvant (CFA), pharmacological removal of GABAergic inhibition or activation of NMDAR in intact rats. The increased SNAP25/syntaxin4/VAMP2/Munc18-1 interaction facilitated the surface delivery and synaptic accumulation of NMDAR during inflammatory pain. Disruption of the molecular interaction between SNAP25 with its SNARE partners by using a blocking peptide derived from the C-terminus of SNAP25 effectively repressed the surface and synaptic accumulation of GluN2B-containing NMDARs in CFA-injected rats. This peptide also alleviated inflammatory mechanical allodynia and thermal...
Source: Neuroscience - Category: Neuroscience Source Type: research

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Conditions:   Spinal Cord Injury;   Inflammation;   Neuropathic Pain Interventions:   Other: Anti-inflammatory Diet;   Other: Placebo Diet Sponsors:   Lawson Health Research Institute;   Ontario Neurotrauma Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
National Random Acts of Kindness (RAK) Day is devoted to just that: People doing random, unasked for gestures, big and small, to make the world a better, kinder place.  There are different stories about how it began. In the U.S., the National Random Acts of Kindness Day was created in 1995 by the Random Acts of Kindness Foundation, a small nonprofit organization. They selected February 17 as the annual day to recognize and support more purposeful kindness.  New Zealand also claims founding credit. RAK day has been an annual day of celebration of kindness there on September 1 for the past 15 years. Josh de Jong is...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Happiness Inspiration & Hope Motivation and Inspiration Compassion Random Acts of Kindness Day Source Type: blogs
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
About one in seven people live with what's ranked the second-most debilitating disease on the planet, right after back pain: migraine. Though the causes are unclear, migraine is a serious neurological disease that often runs in families. But the malady is not often taken seriously, in part because the headaches, sensitivity to light and sound, nausea, dizziness, and a host of other symptoms affect three times as many women as men. Correspondent Susan Spencer talks with migraine expert Dr. William Young; Linda Porter, of the National Institute of Neurological Disorders and Stroke, about migraine research; Katherine Foxhall,...
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
ConclusionsThese data suggest OXT ÔÇÉrelated modulation of regional activity and neural network strength in patients with cLBP and healthy controls. In patients, distinct regions of the pain matrix may be responsive to modulation by OXT.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Pain is an unpleasant sensory and emotional experience in many diseases and is often caused by intense or damaging stimuli. Pain negatively affects the quality of life and increases high health expenditures. Drugs with analgesic properties are commonly used to relieve pain, but these Western medications could be overwhelmed by side effects including tolerance and addiction. Herbal medicines may provide alternative measures for pain management. In this review paper, after introduction of Chinese medicine theory and treatment modality, emphasis is placed on the application of Chinese herbs and herbal formul...
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research
Hey everyone, So I recently got a chance to do a PM&R rotation and to see some of the procedures they do fairly often in the outpatient setting. I was wondering how much exposure neurology gets to some of these procedures in residency / in general without doing a pain fellowship. In trigger point injections or steroid joint injections for back and hips seem pretty easy, and a lot of times people get referred to neuro with back pain even if there is no nerve involvement. It seems nice to be... Pain Procedures in Residency
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Neurology Source Type: forums
Would anyone inject? Patient with bilateral leg weakness.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
No abstract available
Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research
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