Dysregulation of Notch signaling in cardiac mesenchymal cells of patients with tetralogy of Fallot.

CONCLUSIONS: The data suggest a contribution of dysregulated Notch signaling to the pathogenesis of tetralogy of Fallot and importance of Notch signaling level for the functional state of cardiac mesenchymal cells, which could be critical considering these cells for potential cell therapy approaches.
PMID: 31952074 [PubMed - as supplied by publisher]

Source: Pediatric Research - January 16, 2020 Category: Pediatrics Authors: Kozyrev I, Dokshin P, Kostina A, Kiselev A, Ignatieva E, Golovkin A, Pervunina T, Grekhov E, Gordeev M, Kostareva A, Malashicheva A Tags: Pediatr Res Source Type: research