Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer ’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once.
Source: Acta Neuropathologica - Category: Neurology Source Type: research

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Chronic inflammation is an important component of degenerative aging. Excessive inflammatory signaling and activation of the immune system arises due to a combination of many factors, of which some are more important than others, such as the presence of lingering senescent cells. Most of the research focused on controlling inflammation is more interested in sabotaging the mechanisms of control than in removing root causes, however. The work here is an example of the type, in which scientists identify an important feature of the regulatory system controlling inflammation. Forcing a sizable reduction of inflammation via this...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Publication date: Available online 11 February 2020Source: Pharmacological ResearchAuthor(s): Minghua Wu, Min Li, Jun Yuan, Sen Liang, Zhaoyao Chen, Min Ye, Paul M. Ryan, Cain Clark, Shing Cheng Tan, Jamal Rahmani, Hamed kord Varkaneh, Akshaya Srikanth BhagavathulaAbstractHormone therapy continues to be a favourable option in the management of menopausal symptomatology, but the associated risk-benefit ratios with respect to neurodegenerative diseases remain controversial. The study aim was to determine the relation between menopausal hormone therapy and Alzheimer's disease, dementia, and Parkinson's disease in human subjec...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Abstract The structural integrity and functional stability of organelles are prerequisites for the viability and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases. In fact, those organelles synchronously present with evident structural derangement and aberrant function under exposure to different stimuli, which might accelerate the corruption of cells. Therefore, the quality control of multiple organelles is of gr...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
Title: Gene Variant Ups Dementia Risk in Parkinson's Patients: StudyCategory: Health NewsCreated: 2/6/2020 12:00:00 AMLast Editorial Review: 2/7/2020 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news
THURSDAY, Feb. 6, 2020 -- A genetic variant associated with Alzheimer's disease increases the risk of dementia in people with Parkinson's disease, researchers say. The finding could lead to new treatments for dementia in Parkinson's patients,...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Abstract This review is devoted to comparative pharmacological analysis of synthetic drugs such as memantine and its isomers, as well as tacrine, velnacrine, rivastigmine, and donepezil, with natural alkaloids, terpenoids, and triterpenoid peroxides, which are used to treat dementia, Alzheimer's and Parkinson's diseases, myasthenia gravis and other neurodegenerative diseases. Recently discovered by French scientists from Marseille triterpenoid hydroperoxides demonstrate high activity as potential therapeutic agents for the treatment of dementia. The information presented in this review is of great interest to phar...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
The apolipoprotein E (APOE) 4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease mainly by driving amyloid-β pathology. Recently, APOE4 has also been found to be a genetic risk factor for Lewy body dementia (LBD), which includes dementia with Lewy bodies and Parkinson’s disease dementia. How APOE4 drives risk of LBD and whether it has a direct effect on α-synuclein pathology are not clear. Here, we generated a mouse model of synucleinopathy using an adeno-associated virus gene delivery of α-synuclein in human APOE-targeted replacement mice expressing APOE2, APOE3, or...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Cortical swollen neurons with achromasia, described as ballooned neurons (BNs), are hallmark of neurodegenerative diseases such as Pick body disease, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and argyrophilic grain disease (AGD) [1]. BNs are also found less frequently in Alzheimer's disease (AD) and Parkinson's disease (PD), while their role in pathological differentiation remains to be clarified [2]. We experienced an autopsy case with abundant BNs in a 94-year-old man with clinico-pathologically confirmed dementia with Lewy bodies (DLB).
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Conclusions: The pattern of cortical thinning is similar in DLB and PD-associated cognitive impairment, overlapping with and extending beyond AD signature regions to involve fusiform, precentral, and paracentral regions. Cortical thinning in AD signature and fusiform regions in these diseases reflects cognitive impairment and is markedly accentuated by amyloid co-pathology. Further work will be required to determine whether the distinct topography of cortical thinning in DLB and PD-associated cognitive impairment might have value as a diagnostic and/ or outcome biomarker in clinical trials.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Incidence increased for non - Alzheimer dementia, Parkinson, Alzheimer disease, multiple sclerosis
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Internal Medicine, Neurology, Psychiatry, Journal, Source Type: news
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