Long noncoding RNA UC.98 stabilizes atherosclerotic plaques by promoting the proliferation and adhesive capacity in murine aortic endothelial cells.

In conclusion, our results highlighted the pivotal role of UC.98 in regulating the vulnerability of plaques during AS progression and suggested that UC.98 may be a biomarker of the early diagnosis and prognosis of AS with vulnerable plaques and a potential therapeutic target for slowing AS progression.
PMID: 31942916 [PubMed - as supplied by publisher]

Source: Acta Biochimica et Biophysica Sinica - January 10, 2020 Category: Biochemistry Authors: Fan Z, Zhang Y, Xiao D, Ma J, Liu H, Shen L, Zhang M, He B Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research